MPG.eBooks - Table of Contents: GM2 gangliosidosis

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Bibliographic Details
Main Author:	Mahuran, Don
Format:	eBook
Language:	English
Published:	London Henry Stewart Talks 2007, 2007
Series:	Protein epidemiology : understanding human diseases at the level of protein structure and function
Subjects:	Gangliosidoses, Gm2 / Genetics Hexosaminidase A. Substrate Specificity Gangliosidoses, Gm2 / Physiopathology Tay-sachs Disease Lysosomes Tay-sachs Disease / Genetics Sandhoff Disease / Metabolism Gangliosidoses, Gm2 / Metabolism Sandhoff Disease / Genetics Tay-sachs Disease / Metabolism Dimerization G(m2) Ganglioside Beta-n-acetylhexosaminidases / Chemistry
Online Access:	https://hstalks.com/bs/p/33 https://hstalks.com/bs/53
Collection:	Henry Stewart Talks - Collection details see MPG.ReNa

Table of Contents:

GM2 gangliosidosis: the disease and the associated system of beta-hexosaminidase isozymes
Structure-function relationships
What have naturally occurring mutations told us?
Why is dimerization necessary for activity if both subunits have active sites?
What is the basis for the substrate-specificity differences between the active sites of the two subunits?
Why can only heterodimeric hexosaminidase A hydrolyze GM2 ganglioside?