|
|
|
|
| LEADER |
02443nmm a2200409 u 4500 |
| 001 |
EB001082616 |
| 003 |
EBX01000000000000000842023 |
| 005 |
00000000000000.0 |
| 007 |
cr||||||||||||||||||||| |
| 008 |
151019 ||| eng |
| 100 |
1 |
|
|a Mahuran, Don
|
| 245 |
0 |
0 |
|a GM2 gangliosidosis
|h Elektronische Ressource
|c Don Mahuran
|
| 246 |
3 |
1 |
|a GM2 gangliosidoses
|
| 260 |
|
|
|a London
|b Henry Stewart Talks
|c 2007, 2007
|
| 300 |
|
|
|a 1 online resource (1 streaming video file (39 min.)
|b color, sound)
|
| 505 |
0 |
|
|a GM2 gangliosidosis: the disease and the associated system of beta-hexosaminidase isozymes -- Structure-function relationships -- What have naturally occurring mutations told us? -- Why is dimerization necessary for activity if both subunits have active sites? -- What is the basis for the substrate-specificity differences between the active sites of the two subunits? -- Why can only heterodimeric hexosaminidase A hydrolyze GM2 ganglioside?
|
| 653 |
|
|
|a Gangliosidoses, GM2 / genetics
|
| 653 |
|
|
|a Hexosaminidase A.
|
| 653 |
|
|
|a Substrate Specificity
|
| 653 |
|
|
|a Gangliosidoses, GM2 / physiopathology
|
| 653 |
|
|
|a Tay-Sachs disease
|
| 653 |
|
|
|a Lysosomes
|
| 653 |
|
|
|a Tay-Sachs Disease / genetics
|
| 653 |
|
|
|a Sandhoff Disease / metabolism
|
| 653 |
|
|
|a Gangliosidoses, GM2 / metabolism
|
| 653 |
|
|
|a Sandhoff Disease / genetics
|
| 653 |
|
|
|a Tay-Sachs Disease / metabolism
|
| 653 |
|
|
|a Dimerization
|
| 653 |
|
|
|a G(M2) Ganglioside
|
| 653 |
|
|
|a beta-N-Acetylhexosaminidases / chemistry
|
| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
|
| 989 |
|
|
|b HST
|a Henry Stewart Talks
|
| 490 |
0 |
|
|a Protein epidemiology : understanding human diseases at the level of protein structure and function
|
| 500 |
|
|
|a Animated audio-visual presentation with synchronized narration. - Title from title frames. - Mode of access: World Wide Web. - System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v4.0+, iPhone 4+ (iOS v6.x+), iPad 2+ (iOS v6.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
|
| 856 |
4 |
2 |
|u https://hstalks.com/bs/p/33
|3 Series
|
| 856 |
4 |
0 |
|u https://hstalks.com/bs/53
|x Verlag
|z Streaming video file
|
| 082 |
0 |
|
|a 570
|