Table of Contents:
  • Introduction to Alzheimer's disease
  • Morphological and functional features
  • Genetic studies
  • Presenilin functions and calcium homeostasis
  • Calcium dyshomeostasis and FAD
  • Modulatory role of presenilin on IP3-evoked Calcium release
  • Different effects of PS mutants on intracellular Calcium stores
  • A reformulation of the "Calcium hypothesis" for FAD.