Eosinophils
| Main Author: | |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
London
Henry Stewart Talks
2009, 2009
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| Series: | Innate immunity : host recognition and response in health and disease
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| Subjects: | |
| Online Access: | |
| Collection: | Henry Stewart Talks - Collection details see MPG.ReNa |
Table of Contents:
- White blood cell containing granules staining pink with eosin and a bilobed nucleus
- Specialised for defence against worm infection
- Accumulate in high numbers in lungs of allergic asthmatic patients
- Also involved in hay fever, allergic eczema etc
- Induce tissue damage and organ dysfunction when inappropriately activated
- Interleukin-5 (IL-5) important for eosinophil production in bone marrow
- Anti-IL-5 antibodies suppress circulating eosinophil numbers
- Eotaxin is a chemoattractant protein involved in recruiting eosinophils to the lung
- Small molecule antagonists have been developed to block the Eotaxin receptor, CCR3, as potential therapeutic compounds