Function and regulation of the PDK1 kinase
| Main Author: | |
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| Format: | eBook |
| Language: | English |
| Published: |
London
Henry Stewart Talks
2010, 2010
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| Series: | Protein phosphorylation
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| Subjects: | |
| Online Access: | |
| Collection: | Henry Stewart Talks - Collection details see MPG.ReNa |
Table of Contents:
- The insulin cascade
- Approaches to study the insulin signalling pathway
- GSK3 regulation of glycogen synthase by insulin
- Inactivation of GSK3 by PI3K
- GSK3 inactivation by other kinases
- Protein Kinase B (Akt)
- PKB signal transduction
- Substrate specificity of PKB
- Activation of PKB by insulin
- Phosphorylation of PKB on Thr308 and Ser473
- PKB phosphorylation on the catalytic domain
- How insulin locates PKB to the plasma membrane
- PKB translocation to the cell membrane
- Molecular mechanism of PKB activation
- Phosphorylation of PKB
- Discovery of PDK1
- Primary structure of human PDK1
- PIP3 requirement for PDK1 activation of PKB
- PDK1/2 phosphorylation of PKB
- The inability of PIP3 to activate PDK1 in vitro
- PKB in muscle-specific PDK1 knockout mice
- Glycogen synthase inactivation by GSK3
- GSK3 & glycogen synthase in muscle-specific PDK1 knockout mice
- GSK3 knock-in mice
- Analysis of GSK3 isoforms in knock-in mice
- Glycogen sy