Table of Contents:
  • Mucosal tissues of the human body
  • Intestinal pathogens
  • Mucosal immune system: distinctive features
  • Gut-associated lymphoid tissue (GALT)
  • Structure of the GALT: small and large intestine
  • Mucus, a key protective barrier
  • Antimicrobial proteins protect the epithelium
  • Epithelial cell transcytosis of secretory IgA
  • Uptake and transport of antigen by M cells
  • Microbial sensing regulates intestinal homeostasis
  • Sensing of microbes occurs through PRR
  • MyD88 signals in IEC
  • Intestinal macrophages are anti-inflammatory
  • Intestinal DC 'conditioning'
  • Inflammatory bowel disease (IBD)
  • Genome-wide association studies
  • The enigma of NOD2 and Crohn's disease
  • NOD2 signaling in response to bacterial MDP
  • NOD2 signaling regulates myeloid cell function
  • Autophagy also regulates IEC and myeloid cells
  • MyD88 activation drives intestinal inflammation
  • Haematopoeitic MyD88 signals
  • Immune dysregulation in chronic inflammation
  • Innate lymphoid