Table of Contents:
  • Calcium and Signaling
  • Excessive calcium causes cellular stress
  • Signaling pathways are turned on to combat this stress
  • In budding yeast, these pathways involve nuclear translocation of transcriptional regulator Crz1
  • Examination of this regulator shows that nuclear translocation occurs in "bursts"
  • Bursts are quantized and frequency-modulated
  • Frequency modulation enables proportional expression of downstream target genes