Dynamic signal encoding in the S. cerevisiae calcium response
Main Author: | |
---|---|
Format: | eBook |
Language: | English |
Published: |
London
Henry Stewart Talks
2013, 2013
|
Series: | Calcium signaling I : regulation, mechanisms, effectors, role in disease and recent advances
|
Subjects: | |
Online Access: | |
Collection: | Henry Stewart Talks - Collection details see MPG.ReNa |
Table of Contents:
- Calcium and Signaling
- Excessive calcium causes cellular stress
- Signaling pathways are turned on to combat this stress
- In budding yeast, these pathways involve nuclear translocation of transcriptional regulator Crz1
- Examination of this regulator shows that nuclear translocation occurs in "bursts"
- Bursts are quantized and frequency-modulated
- Frequency modulation enables proportional expression of downstream target genes