MPG.eBooks - Table of Contents: Postsynaptic scaffold proteins in health and disease

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Bibliographic Details
Main Author:	Hanley, Jonathan
Format:	eBook
Language:	English
Published:	London Henry Stewart Talks 2014, 2014
Series:	Synapses, neurotransmitters and receptor channels
Subjects:	Protein-protein Interactions Brain Diseases / Physiopathology Neuronal Plasticity / Physiology Synaptic Transmission / Physiology Nerve Tissue Proteins / Metabolism Brain / Diseases / Pathophysiology Neuronal Plasticity Synapses / Physiology
Online Access:	https://hstalks.com/bs/2777 https://hstalks.com/bs/p/798
Collection:	Henry Stewart Talks - Collection details see MPG.ReNa

Table of Contents:

Multi-domain structure of scaffold proteins allows multiple protein-protein interactions
They localise important signaling proteins close to neurotransmitter receptor complexes
Scaffold proteins at excitatory synapses underpin synaptic plasticity by regulating AMPA receptor trafficking and dendritic spine morphology
Mutations in scaffold proteins underlie neuropsychiatric diseases such as autism and schizophrenia
Other diseases including Alzheimers and stroke also involve mechanisms incorporating postsynaptic scaffold proteins