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Mismatch repair deficient cancers diagnosis, treatment and prevention

Bibliographic Details
Main Author: Burn, John
Format: eBook
Language:English
Published: London Henry Stewart Talks 2014, 2014
Series:Molecular genetics of human disease
Subjects:
Colorectal Neoplasms, Hereditary Nonpolyposis
Colon (anatomy) / Cancer / Treatment
Aspirin
Colon (anatomy) / Cancer / Genetic Aspects
Biological Markers
Molecular Genetics
Medical Genetics
Rectum / Cancer / Genetic Aspects
Dna Mismatch Repair
Genetics, Medical
Colorectal Neoplasms / Diagnosis
Colorectal Neoplasms / Genetics
Microsatellite Repeats
Cancer / Genetic Aspects
Microsatellite Instability
Colorectal Neoplasms / Therapy
Rectum / Cancer / Treatment
Aspirin / Therapeutic Use
Online Access:
Collection: Henry Stewart Talks - Collection details see MPG.ReNa
Table of Contents:
  • Lynch syndrome (underlying single gene defect)
  • Microsatellites
  • Important genes containing repeat sequences
  • MSI testing (5 marker panel)
  • Mismatch repair (MMR)
  • The genomic pathogenesis of colorectal cancer (CRC)
  • EGFR and BRAF mutant inhibition
  • BRAF colon cancer project
  • Methotrexate & MMR deficient tumours
  • Africans & bowel cancer (Dennis Burkitt)
  • Cancer prevention program (CaPP)
  • NSAIDs and reduced colorectal cancer risk
  • Aspirin effect on polyps in FAP and colorectal adenoma
  • The prevention paradox
  • CaPP2 (Colorectal & Lynch syndrome cancers)
  • Meta-analysis of cancer deaths with aspirin treatment
  • CRCs in people on aspirin (mostly COX2 negative)
  • Individual response to aspirin in cancer prevention
  • History of salicylate as an essential nutrient
  • CaPP3 study
  • Peptides created by slippage in microsatellite coding
  • Antibodies as a possible biomarker for Lynch syndrome
  • The Micoryx vaccine

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