Evolution of translational omics lessons learned and the path forward

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detec...

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Corporate Author: Institute of Medicine (U.S.) Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Other Authors: Micheel, Christine (Editor), Nass, Sharyl J. (Editor), Omenn, Gilbert S. (Editor)
Format: eBook
Language:English
Published: Washington, D.C. National Academies Press [2012], 2012
Subjects:
Online Access:
Collection: National Center for Biotechnology Information - Collection details see MPG.ReNa
Summary:Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials
Item Description:Title from PDF t.p
Physical Description:1 online resource (1 PDF file (xv, 338 pages) illustrations
ISBN:0309224187
9780309224185