Practice-based interventions addressing concomitant depression and chronic medical conditions in the primary care setting

Sample sizes ranged from 55 to 1,001, and study duration ranged from 6 to 60 months. Eleven studies were conducted in the United States (1 in Puerto Rico) and 1 in Scotland. All studies characterized their respective intervention as a form of collaborative care compared with usual or enhanced usual...

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Main Authors: Watson, Lea, Amick, Halle R. (Author), Gaynes, Bradley N. (Author), Brownley, Kimberly Ann (Author)
Corporate Authors: United States Agency for Healthcare Research and Quality, RTI International-University of North Carolina Evidence-based Practice Center, Effective Health Care Program (U.S.)
Format: eBook
Language:English
Published: Rockville, MD Agency for Healthcare Research and Quality [2012], 2012
Series:Comparative effectiveness review
Subjects:
Online Access:
Collection: National Center for Biotechnology Information - Collection details see MPG.ReNa
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100 1 |a Watson, Lea 
245 0 0 |a Practice-based interventions addressing concomitant depression and chronic medical conditions in the primary care setting  |h Elektronische Ressource  |c prepared for, Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by, RTI International--University of North Carolina Evidence-based Practice Center ; investigators, Lea Watson, M.D., M.P.H., Halle R. Amick, M.S.P.H., Bradley N. Gaynes, M.D., M.P.H., Kimberly A. Brownley, Ph.D., Samruddhi Thaker, M.B.B.S., M.H.A., Ph.D., Meera Viswanathan, Ph.D., Daniel E. Jonas, M.D., M.P.H. 
260 |a Rockville, MD  |b Agency for Healthcare Research and Quality  |c [2012], 2012 
300 |a 1 online resource (1 PDF file (various pagings))  |b illustrations 
505 0 |a Includes bibliographical references 
653 |a Comparative Effectiveness Research 
653 |a Primary Health Care 
653 |a Chronic Disease / psychology 
653 |a Depressive Disorder / therapy 
653 |a Depressive Disorder / complications 
653 |a Treatment Outcome 
653 |a Cooperative Behavior 
700 1 |a Amick, Halle R.  |e [author] 
700 1 |a Gaynes, Bradley N.  |e [author] 
700 1 |a Brownley, Kimberly Ann  |e [author] 
710 2 |a United States  |b Agency for Healthcare Research and Quality 
710 2 |a RTI International-University of North Carolina Evidence-based Practice Center 
710 2 |a Effective Health Care Program (U.S.) 
041 0 7 |a eng  |2 ISO 639-2 
989 |b NCBI  |a National Center for Biotechnology Information 
490 0 |a Comparative effectiveness review 
500 |a Title from PDF title page. - "Contract No. 290-2007-10056-I.". - "August 2012." 
856 |u http://www.ncbi.nlm.nih.gov/books/NBK100652  |3 Volltext 
082 0 |a 610 
082 0 |a 100 
520 |a Sample sizes ranged from 55 to 1,001, and study duration ranged from 6 to 60 months. Eleven studies were conducted in the United States (1 in Puerto Rico) and 1 in Scotland. All studies characterized their respective intervention as a form of collaborative care compared with usual or enhanced usual care, and generally involved a care manager with physician supervision; we found no studies describing other types of practice-based interventions. Settings of care for included studies, although rarely characterized, included both open and closed systems. All studies specified depression as the targeted mental health condition. Medical conditions included arthritis, cancer, diabetes, heart disease, HIV, and one or more conditions.  
520 |a OBJECTIVES: For adults with concomitant depression and chronic medical conditions seen in the primary care setting, to assess the effectiveness of practice-based interventions for improving mental health or medical outcomes. DATA SOURCES: We searched MEDLINE(r), Embase, the Cochrane Library, CINAHL(r), and PsycINFO(r) from inception to December 2011. We identified additional studies from reference lists and technical experts. REVIEW METHODS: Two people independently selected, extracted data from, and rated the quality of relevant trials and systematic reviews. We conducted quantitative analyses for outcomes when feasible and reported all results by medical condition when possible. Two reviewers graded the strength of evidence (SOE) using established criteria. RESULTS: We included 24 published articles reporting data from 12 studies (9 randomized controlled trials and 3 preplanned subgroup analyses from a tenth trial).  
520 |a Future studies should be designed to target a broader range of medical conditions, or clusters of conditions, and should compare variations of practice-based interventions in head-to-head trials 
520 |a Our meta-analyses found that intervention recipients achieved greater improvement than controls in depression symptoms, response, remission, and depression-free days (moderate SOE); satisfaction with care (moderate SOE); and mental and physical quality of life (moderate SOE). Few data were available on outcomes for chronic medical conditions, except for diabetes; only one trial used a medical outcome as the primary outcome. Diabetic patients receiving collaborative care exhibited no difference in diabetes control as compared with control groups (change in HbA1c: weighted mean difference 0.13, 95% CI, 0.22 to 0.48 at 6 months; 0.24, 95% CI, 0.14 to 0.62 at 12 months; low SOE). CONCLUSIONS: Collaborative care interventions improved outcomes for depression and quality of life in primary care patients with multiple different medical conditions. Few data were available on medical outcomes, except for HbA1c in diabetes, which showed no difference between treatment and usual care.