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150223 r ||| eng |
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|a MacLean, Catherine H.
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|a Comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis
|h Elektronische Ressource
|c prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by Southern California/RAND Evidence-based Practice Center ; prinicipal investigator, Catherine MacLean ; research team, Alicia Alexander ... [et al.]
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|a [Rockville, MD
|b Agency for Healthcare Research and Quality
|c 2007, 2007]
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|a 1 PDF file (1 v. (various pagings
|b ill.)
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|a Includes bibliographical references
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|a Comparative Effectiveness Research
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|a Bone Density
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|a Osteoporosis / drug therapy
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| 653 |
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|a Randomized Controlled Trials as Topic
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| 653 |
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|a Bone Density Conservation Agents / therapeutic use
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| 653 |
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|a Osteoporotic Fractures / prevention & control
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|a Alexander, Alicia
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|a United States
|b Agency for Healthcare Research and Quality
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|a Southern California Evidence-Based Practice Center/RAND.
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|a eng
|2 ISO 639-2
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|b NCBI
|a National Center for Biotechnology Information
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|a Comparative effectiveness review
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|a Title from PDF t.p. (viewed Aug. 30, 2011). - "December 2007.". - "Contract no. 290-02-0003."
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|u https://www.ncbi.nlm.nih.gov/books/NBK43160
|3 Volltext
|n NLM Bookshelf Books
|3 Volltext
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|a 610
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|a This Comparative Effectiveness Review (CER) compares the benefits in fracture reduction and the harms from adverse events (AE) among and within the various classes of treatment for low bone density. Our outcomes of interest for measuring benefits are vertebral, non-vertebral, hip, and radial fractures. The studies collect vertebral fracture outcomes in one of two ways. In some studies, all participants undergo radiography at pre-determined intervals. Other studies use clinical criteria, i.e. whether a fracture has been diagnosed by a clinician during the time interval. Trials that radiograph all participants will by nature detect more fractures. However the higher detection rate will apply to both treatment and placebo groups. Thus, the relative differences found should be similar that found in studies that use clinical criteria
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