Pre-Analytics of Pathological Specimens in Oncology

This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase – the period from surgical removal of tissue to the start of pat...

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Corporate Author: SpringerLink (Online service)
Other Authors: Dietel, Manfred (Editor), Wittekind, Christian (Editor), Bussolati, Gianni (Editor), Winterfeld, Moritz (Editor)
Format: eBook
Language:English
Published: Cham Springer International Publishing 2015, 2015
Edition:1st ed. 2015
Series:Recent Results in Cancer Research
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
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100 1 |a Dietel, Manfred  |e [editor] 
245 0 0 |a Pre-Analytics of Pathological Specimens in Oncology  |h Elektronische Ressource  |c edited by Manfred Dietel, Christian Wittekind, Gianni Bussolati, Moritz Winterfeld 
250 |a 1st ed. 2015 
260 |a Cham  |b Springer International Publishing  |c 2015, 2015 
300 |a VI, 133 p. 65 illus., 61 illus. in color  |b online resource 
505 0 |a What Is Pre-Analytics in Surgical Pathology? -- Histologic Validation of Vacuum Sealed Formalin -- Free Tissue Preservation and Transport System -- Pre-Analytics and Molecular Pathology -- Experiences in Vacuum Preparation of Routine Specimens -- Tissue Heterogeneity as a Pre-Analytical Source of Variability -- Vacuum Fixation of Breast Specimens Before Grossing -- How Do Short Fixation and Rapid Microwave Processing Affect Her2 Testing? -- Current Projects in Pre-Analytics – Where to Go? -- Nucleic Acid Extraction from FFPE Tissue as Critical Preanalytic Step for NGS Applications -- Experiences With Pre-Analytics of Lung Specimen -- Experiences With Pre-Analytics of GI-Specimen -- Bone Marrow Work-Up -- Two-Temperature Fixation Preserves Activation Status with High Efficiency -- Towards the Lean Lab. The Industry Challenge.   
653 |a Pathology 
653 |a Oncology   
653 |a Oncology 
653 |a Surgery 
653 |a Laboratory Medicine 
653 |a Pathology 
653 |a Laboratory medicine 
653 |a Surgery 
700 1 |a Wittekind, Christian  |e [editor] 
700 1 |a Bussolati, Gianni  |e [editor] 
700 1 |a Winterfeld, Moritz  |e [editor] 
710 2 |a SpringerLink (Online service) 
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989 |b Springer  |a Springer eBooks 2005- 
490 0 |a Recent Results in Cancer Research 
856 |u https://doi.org/10.1007/978-3-319-13957-9?nosfx=y  |x Verlag  |3 Volltext 
082 0 |a 616.994 
520 |a This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase – the period from surgical removal of tissue to the start of pathological processing – have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up