Extrasynaptic GABAA Receptors

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhib...

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Bibliographic Details
Other Authors: Errington, Adam C. (Editor), Di Giovanni, Giuseppe (Editor), Crunelli, Vincenzo (Editor)
Format: eBook
Language:English
Published: New York, NY Springer New York 2014, 2014
Edition:1st ed. 2014
Series:The Receptors
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • A brief introduction to extrasynaptic GABAA receptors and ‘tonic’ GABAA receptor mediated inhibition in physiology and disease
  • Extrasynaptic GABAA receptors: subunit composition, distribution, and regulation
  • Biophysical properties of recombinant 2- AND δ- subunit containing GABAA receptors
  • The pharmacology of extrasynaptic GABAA receptors
  • Neurosteroids and extrasynaptic GABAA receptors
  • Sources of GABA that activate extrasynaptic GABAA receptors
  • Modulation of Extrasynaptic GABAA Receptors by G-protein-coupled Receptors
  • Extrasynaptic GABAA receptors and tonic inhibition in spinal cord
  • The role of peri-synaptic GABA receptors after stroke
  • The role of extrasynaptic GABAA receptors in focal epilepsy
  • Gain-of-Function of Thalamic Extrasynaptic GABA-A Receptors in Typical Absence Seizures
  • GABAergic control of the hypothalamic-pituitary-adrenal (HPA) axis: role of extrasynaptic GABAA receptors
  • Tonic GABAA receptor mediated inhibition in Fragile-X Syndrome: A cause of dysfunction or a pathway for a cure?