Aging and Heart Failure Mechanisms and Management

This book synthesizes the major research advances in molecular, biochemical, and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure...

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Bibliographic Details
Other Authors: Jugdutt, Bodh I. (Editor)
Format: eBook
Language:English
Published: New York, NY Springer New York 2014, 2014
Edition:1st ed. 2014
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Effect of right ventricular and pulmonary artery remodeling
  • Biomarkers of cardiovascular aging
  • Changes in the heart that accompany advancing age: Humans to molecules
  • Aging-related changes in cell death and cell survival pathways and implications for heart failure therapy
  • Aging-related changes in telomeres and telomerases and implications for heart failure therapy
  • pathophysiological perspectives and clinical implications
  • Aging-related changes in extracellular matrix: implications for ventricular remodeling following myocardial infarction
  • Calcium handling defects and changes in cardiac function in the aging heart
  • Integrins: Implications for aging in heart failure therapy
  • Adipokines as novel biomarkers in aging and heart failure
  • Aging-related changes in cellular and molecular mechanisms of post-infarction remodeling. Implications for heart failure therapy
  • Aging-related changes in mitochondrial function and implication for heart failure therapy
  • Regulation of SERCA via oxidative modifications: Implications for the pathophysiology of diastolic dysfunction in the aging heart
  • SMP-30 and aging-related cardiac remodeling and heart failure
  • an update on clinical trials and opportunities for therapy