Maximal Myocardial Perfusion as a Measure of the Functional Significance of Coronary Artery Disease From a Pathoanatomic to a Pathophysiologic Interpretation of the Coronary Arteriogram

Coronary flow reserve is a functional measure of stenosis severity re­ flecting the integrated effects of its geometry including percent stenosis, absolute lumen area, length and shape. Its clinical application has been primarily qualitative in non-invasive, perfusion imaging. Measurement of coronar...

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Bibliographic Details
Main Author: Pijls, N.H.
Format: eBook
Language:English
Published: Dordrecht Springer Netherlands 1991, 1991
Edition:1st ed. 1991
Series:Developments in Cardiovascular Medicine
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • 4.5 Prerequisites for myocardial flow assessment by videodensitometry, according to the physiology of indicator dilution theory
  • 5 A Model Study to Validate Calculation of Myocardial Blood Flow by Videodensitometry
  • 5.1 Introduction
  • 5.2 Materials and methods
  • 5.3 Results
  • 5.4 Discussion
  • 5.5 Conclusions
  • 6 Mean Transit Time for the Assessment of Myocardial Perfusion by Videodensitometry
  • 6.1 Introduction
  • 6.2 Methods
  • 6.3 Results
  • 6.4 Discussion
  • 6.5 Clinical implications and limitations
  • 7 The Concept of Maximal Flow Ratio for Immediate Evaluation of PTCA Result
  • 7.1 Introduction
  • 7.2 Methods
  • 7.3 Results
  • 7.4 Discussion
  • 7.5 Limitations
  • 8 Reproducibility of Mean Transit Time for Maximal Myocardial Flow Assessment
  • 8.1 Introduction
  • 8.2 Methods
  • 8.3 Results
  • 8.4 Discussion
  • 9 General Discussion
  • 9.1 Discussion
  • 9.2 Conclusions
  • 9.3 Limitations
  • 9.4 Spin-off and Present Applications
  • 1 Introduction
  • 1.1 The limited value of classical coronary arteriography to predict the physiologic significance of coronary artery stenoses
  • 1.2 Coronary flow reserve
  • 1.3 Maximal coronary and myocardial blood flow
  • 2 Methods of Measuring Myocardial Blood Flow
  • 2.1 Laboratory methods
  • 2.2 Clinical methods
  • 3 Application of Indicator Dilution Theory in the Investigation of the Cardiovascular System
  • 3.1 History
  • 3.2 The two approaches in indicator dilution theory
  • 3.3 Videodensitometry and digital arteriography for flow assessment in the coronary circulation
  • 4 Problems and Limitations in the Application of Videodensitometry to Assess Coronary Blood Flow and Myocardial Perfusion
  • 4.1 Influence of the contrast agent on flow
  • 4.2 Changes in vascular volume
  • 4.3 Contrast density vs contrast concentration
  • 4.4 Difficulties in determination of mean transit time due to motion and insufficient image quality
  • A Is Nonionic Isotonic Iohexol the Contrast Agent of Choice for Quantitative Myocardial Videodensitometry?
  • A.1 Introduction
  • A.2 Methods
  • A.3 Results
  • A.4 Discussion
  • A.5 Conclusion
  • B Fitting Procedures for Time-Density Curves
  • Summary