%0 eBook %M Solr-EB000691335 %E Vries, Jan E.de %E Waal Malefyt, Rene de %I Springer Berlin Heidelberg %D 1995 %C Berlin, Heidelberg %G English %B Molecular Biology Intelligence Unit %@ 9783662220382 %T Interleukin-10 %U https://doi.org/10.1007/978-3-662-22038-2?nosfx=y %7 1st ed. 1995 %X The presented information reflects a state-of-the-art summary of the pleiotropic effects of IL-10 in vitro and in vivo and will contribute to our understanding of the role of ILj-10 in the immune system and its potential clinicial utility in the near future. The book contains chapters in which the in vitro biological effects of IL-10 on both mouse and human lymphoid and myeloid cells are reviewed. In addition, the role of IL-10 in transplantation, parasite infections, inflammation, infectious diseases and bone formation is described. The effects of IL-10 in vivo are presented, describing an IL-10 transgenic mouse model, the IL-10 "knock-out" mouse, and the capacity of IL-10 to prevent lethal toxic shock in mice