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140122 ||| eng |
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|a 9783642914638
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| 100 |
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|a Clark, A.J.
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| 245 |
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|a General Pharmacology
|h Elektronische Ressource
|c by A.J. Clark
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| 250 |
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|a 1st ed. 1937
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| 260 |
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|a Berlin, Heidelberg
|b Springer Berlin Heidelberg
|c 1937, 1937
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| 300 |
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|a VI, 230 p. 1 illus
|b online resource
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| 505 |
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|a Delays in Drug Action Due to Diffusion to Cell Surface p. -- Penetration of Cells p. -- Delay in Biological Response p. -- (3) Maximum Rate of Drug Action -- 12: The Rate of Action of Drugs on Cells -- (1) Curves Relating Time and Graded Action -- The Shapes of Time-action Curves p. -- (2) Curves Relating Time and All-or-None Effects -- Kinetics of Protein Precipitation p. -- Precipitation of Protein by Phenol p. -- (3) Time Action Curves as Expressions of Variation -- Calculation of Time-action Curves p. -- Time Relations of Toxic Action of Copper on Algae p. -- (4) Implications of Monomolecular Theory -- Quantitative Measurements of Drug Uptake p. -- Drug Actions as Chain Processes p. -- (5) Mortality Curves -- (6) Action of Radiations -- Discussion p. -- 13: Time-concentrations Curves -- (1) Form of Curves and Possible Significance -- (2) Time-concentration Curves of Nerve Paralysis -- (3) Time-concentration Curves with Various Drugs --
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| 505 |
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|a The Action of Dyes on Enzymes -- Action of Quinine on Enzymes -- Action of Quinine on Cells -- Action of Cyanide on Enzymes and Cells -- Diphasic Actions of Cyanide -- Phenol Compounds -- The Action of Narcotics -- Action of Narcotics on Enzymes -- Action of Narcotics on Cells -- Theories of Narcotic Action -- Discussion -- 8: Concentration-action Relations I -- (1) Classification of Concentration-action Curves -- Relations Depending on Mass-action p. -- All-or-None Effects p. -- (2) Concentration-action Relations Attributable to Mass-action Laws -- The Mode of Action of Acetylcholine p. -- Amount of Aeetylcholine Acting on Cells p. -- Individual Variation p. -- Site of Action of Acetylcholine p. -- Influence of Temperature on Acetylcholine Response p. -- Specificity of Aeetyleholine Action p. -- Possible Nature of Acetylcholine Receptors p. -- Acetylcholine Esterase p. -- Concentration-action Relations of Adrenaline p. -- Dosage of Adrenaline p. --
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| 505 |
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|a 1: Methods of General Pharmacology -- General Considerations -- Selection of Material -- Employment of Physicochemical Methods -- The Mathematical Interpretation of Biological Data -- Favourable Factors in Pharmacological Measurements -- Curves Relating Exposure to Drugs with Biological Effect -- Classes of Curves -- Discussion -- 2: The Cell as a Physicochemical System -- The Structure of Protoplasm -- The Cell Surface -- Cell Permeability -- Structure of Plasmatic Membrane -- Cell Organisation -- 3: General Characteristics of the Cell-Drug System -- Dimensions of Molecules and Cells -- The Number of Molecules in Single Cells -- The Number of Enzyme Molecules per Cell -- Lethal Doses of Drugs per Cell -- Effective Doses of Drugs per Cell -- Minimum Active Doses of Drugs per Organism -- Minimum Active Dilutions of Drugs -- Intracellular Administration of Drugs -- Types of Action of Drugs on Cells -- Discussion -- 4: Reactions between Drugs and Active Proteins --
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| 505 |
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|a Concentration-action Relations Found with Various Hormones p. -- Insulin p. -- Thyroxin p. -- Posterior Pituitary Principles p. -- Sex Hormones p. -- Various Alkaloids p. -- Nicotine p. -- Physostigmine p. -- Other Alkaloids p. -- 9: Concentration-action Relations II -- (3) Linear Relations; Action of Narcotics -- (4) All-or-None Responses -- Instrumental Errors p. -- Distortion by the Cell of some Chemical Relation p. -- Obligatory All-or-None effects p. -- All-or-None Cellular Responses p. -- Concentration-action Curves with Guinea Pig’s Uterus p. -- Drugs Producing All-or-None Effects p. -- Discussion p. -- 10: Quantitative Pharmacology and the Theory of Humoral Transmission -- Quantitative Data -- Rate of Action -- Concentration-action Relations.-Specific Antagonisms -- Discussion -- 11: Kinetics of Drug Action -- Sources of Error in Kinetic Measurements -- (1) Kinetics of Reactions in Heterogenous Systems -- (2) Kinetics of Cell Reaction --
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| 505 |
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|a (4) Time-concentration Relations in Disinfection -- (5) Toxic Vapours -- Deviation of Narcotics p. -- Time-concentration Curves of Anaesthetics p. -- Time-concentration Curves of Hydrocyanic Acid p. -- Irritant Gases p. -- Discussion p. -- 14: Individual Variation of Response to Drugs -- Methods of Measurement of Individual Variation -- Skew Variation in Biological Material -- Normal Equivalent Deviation -- Errors in Construction of Characteristic Curves -- Uniformity of Population -- Errors of Sampling -- 15: Relation between Various Types of Curves Expressing Response of Cells to Drugs -- (1) Concentration-action Curves as Expressions of Individual Variation -- Virus Infections p. -- Discussion p. -- (2) Characteristic Curves as Expressions of Chemical Processes -- (3) Correlation between Concentration-action Curves and Characteristic Curves -- Examples of Skewed Characteristic Curves p. -- All-or-None Effects p. -- Discussion p. -- (4) Drug Responses and Individual Variation --
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| 505 |
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|a Monomolecular Theory -- The Potential Theory of Drug Action -- Phasic response of cells -- Arndt-Schulz Law -- Drug Responses as Expression of Individual Variation -- Weber-Fechner Law -- Discussion -- 20: Quantitative Aspects of Chemotherapy -- Action of Metallic Compounds -- Action of Non-metallic Compounds -- Drug-resistance -- Discussion -- 21: Conclusion -- Index of Authors -- Index of Subjects
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| 505 |
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|a 16: Special Problems Relating to Variation of Populations -- Uniformity of Population -- Influence of Sex, Age and Weight on Response to Drugs -- Seasonal Variations in Sensitivity -- Variation in Human Populations -- Hypersensitivity and Idiosyncrasy -- Margin of Safety with Massive Doses -- Disinfection, etc. -- 17: Quantitative Aspects of Drug Antagonism and of Drug Synergism -- The antagonism of cyanides by narcotics -- Selective Antagonisms with Haemoglobin -- Antagonism in Enzyme Poisoning -- Acetyl Choline-Atropine Antagonism -- Adrenaline-Ergotoxine Antagonism -- Synergists of Adrenaline -- Comparison of Antagonisms found with Enzymes and with Hormones -- 18: Qualitative Aspects of Drug Antagonism -- Antagonism of Adrenaline -- Chemical Structure of Acetyl Choline Antagonists -- Acetyl Choline Antagonism in Different Tissues -- Analysis of Drug Actions by Drug Antagonisms -- General Theory of Drug Antagonisms -- 19: Alternative Theories of Drug Action --
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| 505 |
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|a Symplex Compounds -- Combination of Haemoglobin with Oxygen and Carbon Monoxide -- Antagonism of Oxygen and Carbon Monoxide -- Discussion -- 5: The Action of Drugs on Catalysts and Enzymes -- Poisoning of Inorganic Catalysts -- General Characters of Enzymes -- Enzyme Activity -- General Characters of the Poisoning of Enzymes -- Diphasic Actions of Enzyme Poisons -- The Rate of Action of Enzyme Poisons -- Relation between Concentration of Poison and Inhibition of Enzyme -- Discussion -- 6: Action of Heavy Metals on Enzymes in vitro and in vivo -- Action of Heavy Metals on Saccharase -- Concentration-action Relations of Heavy Metals and Enzymes -- The Action of Metals on Living Cells -- Relation between Metal Concentration and Action on Cells -- Minimum Lethal Concentrations of Heavy Metals -- Relative Toxicity of Metals -- Course of Reaction between Metals and Cells -- Diphasic Actions of Metals on Cells -- Discussion -- 7: Action of Various Enzyme Poisons in vitro and in vivo --
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| 653 |
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|a Medicinal chemistry
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| 653 |
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|a Pharmacy
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| 653 |
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|a Medicinal Chemistry
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| 653 |
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|a Pharmacology
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| 041 |
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7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b SBA
|a Springer Book Archives -2004
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| 490 |
0 |
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|a Handbuch der Experimentellen Pharmakologie
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| 028 |
5 |
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|a 10.1007/978-3-642-91463-8
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| 856 |
4 |
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|u https://doi.org/10.1007/978-3-642-91463-8?nosfx=y
|x Verlag
|3 Volltext
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| 082 |
0 |
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|a 615
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