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140122 ||| eng |
| 020 |
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|a 9783642846311
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| 100 |
1 |
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|a Peakall, David B.
|e [editor]
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| 245 |
0 |
0 |
|a Biomarkers
|h Elektronische Ressource
|b Research and Application in the Assessment of Environmental Health
|c edited by David B. Peakall, Lee R. Shugart
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| 250 |
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|a 1st ed. 1993
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| 260 |
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|a Berlin, Heidelberg
|b Springer Berlin Heidelberg
|c 1993, 1993
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| 300 |
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|a XIX, 119 p
|b online resource
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| 505 |
0 |
|
|a 1. Applications and Objectives of Biomarker Research -- 1.1. Introduction -- 1.2. Definitions -- 1.3. Objectives of Biomarker Programs -- 1.4. Applications of Biomarker Programs -- 1.5. Rationale for the use of Biomarkers -- 1.6. Current Limitations in the use of Biomarkers -- 1.7. Future of Biomarkers in Environmental Assessment -- 1.8. Literature Cited -- 2. The Conceptual Basis of the Biomarker Approach -- 2.1. Introduction -- 2.2. Dose-Response Relationships -- 2.3. Physiological Alterations as a Basis for Biomarkers -- 2.4. Considerations in the use of Biomarkers -- 2.5. Future Prospects -- 2.6. Literature Cited -- 3. Implementation of Biomarker-Based Studies -- 3.1. Introduction -- 3.2. Selection and Characterization of Study Sites -- 3.3. Selection of Species -- 3.4. Biomarker Selection -- 3.5. Sampling Methodology -- 3.6. Analysis -- 3.7. Summary -- 3.8. Literature Cited -- 4. Interpretation of Biomarker Responses -- 4.1. Introduction -- 4.2. Biological Interpretation of Biomarkers -- 4.3. Statistical and Mathematical Techniques for Interpretation -- 4.4. Societal Interpretations -- 4.5. Literature Cited -- 5. Development and Validation of Biomarkers -- 5.1. Introduction -- 5.2. The Ideal Biomarker -- 5.3. Development of new Biomarkers -- 5.4. Validation -- 5.5. Literature Cited -- 6. Conceptual Strategy for Development and Application of a Biomarker-Based Biomonitoring Program -- 6.1. Definition of Study Objectives -- 6.2. General Elements of a Biomarker-Based Biomonitoring Study -- 6.3. Tailoring Study Design for Specific Objectives -- 6.4. Development of Biomarkers: Laboratory and Field Studies -- 6.5. Literature Cited
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| 653 |
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|a Environmental Law
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| 653 |
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|a Environmental health
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| 653 |
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|a Ecology
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| 653 |
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|a Environmental Health
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| 653 |
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|a Ecology
|
| 700 |
1 |
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|a Shugart, Lee R.
|e [editor]
|
| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
|
| 989 |
|
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|b SBA
|a Springer Book Archives -2004
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| 490 |
0 |
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|a Nato ASI Subseries H:, Cell Biology
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| 028 |
5 |
0 |
|a 10.1007/978-3-642-84631-1
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| 856 |
4 |
0 |
|u https://doi.org/10.1007/978-3-642-84631-1?nosfx=y
|x Verlag
|3 Volltext
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| 082 |
0 |
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|a 577
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| 520 |
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|a Biological markers used to assess the effects of environmental pollution have attracted considerable attention from regulatory agencies and are currently under evaluation at a number of research facilities throughout the world. However promising a biomarker-based biomonitoring approach may be, the development of this concept is complicated by a range of technical issues. This book provides a conceptional framework for research and application of biomarkers. International experts on biomonitoring have formulated a unified strategy for the development and validation of biomarkers in assessing environmental health as well as appropriate protocols for their implementation and interpretation in a biological monitoring program
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