Neuromuscular Junction
Has the neuromuscular junction been over-exposed or is it perhaps already a closed book? I asked myself this at a recent International Congress when an American colleague complained that the Journal of Physiology had articles on nothing but the neuromuscular junction, while another colleague asked w...
| Main Authors: | , , , |
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| Format: | eBook |
| Language: | English |
| Published: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1976, 1976
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| Edition: | 1st ed. 1976 |
| Series: | Handbook of Experimental Pharmacology
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| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- H. Axonal Transport of Materials Related to Cholinergic Transmission
- I. Prolonged Neurochemical Changes Resulting from Synaptic Activity
- References
- 3 Transmission of Impulses from Nerve to Muscle
- A. Introduction
- B. The Muscle Fibre and the Action of Acetylcholine
- C. Pre-Synaptic Events
- D. Postscript
- References
- 4A Depolarising Neuromuscular Blocking Drugs
- A. General Introduction
- B. An Introduction to the Pharmacological Actions of Decamethonium at the Neuromuscular Junction
- C. End-Plate Depolarisation by Decamethonium and Suxamethonium in vivo
- D. Effect of Decamethonium, Suxamethonium and Acetylcholine on the Electrical Properties of Single Mammalian Muscle Cells
- E. Depolarisation Versus Desensitisation
- F. Species Differences and Depolarising Neuromuscular Blocking Drugs
- G. Factors which May Modify the Action of Depolarising Neuromuscular Blocking Drugs and Variations Due to Experimental Conditions
- H. Concluding Remarks
- Appendix III An Outline of the Methods Used to Calculate the Quantal Content of the e.p.p. and the Rate of Refilling and Size of the ACh Store in Nerve Terminals
- References
- 5A The Clinician Looks at Neuromuscular Blocking Drugs
- A. Introduction
- B. General Anaesthesia before Neuromuscular Blocking Drugs
- C. Clinical Influence of Neuromuscular Blocking Drugs
- D. Three Possibly Fatal Reactions to Suxamethonium
- E. Less Serious Reactions to Suxamethonium
- F. Personal Technique
- G. Conclusions
- References
- 5B Neuromuscular Blocking Drugs in Man
- A. Introduction
- B. Measurement of Drug Action
- C. Pharmacokinetics of Neuromuscular Blocking Drugs
- D. Action of Neuromuscular Blocking Drugs at the Neuromuscular Junction
- E. Other Actions of Neuromuscular Blocking Drugs
- References
- 5C Twenty Years’ Experience with Decamethonium
- A. Introduction
- B. First Clinical Reports
- C. Analysis of 32000 Administrations of Decamethonium
- D. Assessment
- References
- Author Index
- References
- 4B Competitive Neuromuscular Blocking Drugs
- A. Introduction and Terminology
- B. Chemical Structure
- C. Methods Used to Measure Neuromuscular Blockade
- D. Distribution of Competitive Neuromuscular Blocking Drugs
- E. Factors Affecting Duration of Action in Animals and Man
- F. Mechanism of Action at Neuromuscular Junction
- G. Effects at Cholinergic Synapses in the Autonomic Nervous System
- H. Histamine Release in Animals and Man
- J. Miscellaneous Drugs which Cause Muscle Paralysis
- References
- 4C Pharmacology of Anticholinesterase Drugs
- A. Introduction
- B. Morphology and Function of Acetylcholinesterase (AChE)
- C. Inhibition of AChE
- D. Actions of Anticholinesterases of the Carbamate and Organophosphate Type and of Anilinium Ions
- General Conclusions
- Appendix I Studies on Frog Muscles
- Appendix II Anticholinesterases and Anilinium Ions Referred to in the Text
- Introductory Chapter The Neuromuscular Junction: Areas of Uncertainty
- Neuromuscular Block by Prolonged Depolarisation
- Desensitisation
- The Clinical Picture
- The Presence of Other Drugs
- The Importance of the Drug Structure and that of the Acetylcholine Receptor
- Pre-Synaptic or Post-Synaptic Action?
- Closing Remarks
- References
- 1 The Anatomy and Pathology of the Neuromuscular Junction
- A. Introduction
- B. Normal Muscle
- C. Development, Growth, and Plasticity of the Neuromuscular Junction
- D. The Neuromuscular Junction in Disorders of Transmission
- E. The Neuromuscular Junction in Disorders of the Muscle Fibre
- F. Conclusion
- References
- 2 Neurochemistry of Cholinergic Terminals
- A. Introduction
- B. Methods for Extracting and Measuring Acetylcholine
- C. Acetylcholine Synthesis
- D. Acetylcholine Storage
- E. Acetylcholine Release
- F. Acetylcholine Turnover
- G. Removal of Acetylcholine