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140122 ||| eng |
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|a 9783642454769
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| 100 |
1 |
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|a Bowden, R.E.M.
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| 245 |
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|a Neuromuscular Junction
|h Elektronische Ressource
|c by R.E.M. Bowden, B. Collier, R.D. Dripps, L.W. Duchen, G.E. Hale Enderby, B.L. Ginsborg, S. Head, F. Hobbiger, D.H. Jenkinson, F.C. MacIntosh, J. Maglagan, S.E. Smith, E. Zaimis ; edited by E. Zaimis
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| 250 |
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|a 1st ed. 1976
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| 260 |
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|a Berlin, Heidelberg
|b Springer Berlin Heidelberg
|c 1976, 1976
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| 300 |
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|a XVIII, 748 p
|b online resource
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| 505 |
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|a H. Axonal Transport of Materials Related to Cholinergic Transmission -- I. Prolonged Neurochemical Changes Resulting from Synaptic Activity -- References -- 3 Transmission of Impulses from Nerve to Muscle -- A. Introduction -- B. The Muscle Fibre and the Action of Acetylcholine -- C. Pre-Synaptic Events -- D. Postscript -- References -- 4A Depolarising Neuromuscular Blocking Drugs -- A. General Introduction -- B. An Introduction to the Pharmacological Actions of Decamethonium at the Neuromuscular Junction -- C. End-Plate Depolarisation by Decamethonium and Suxamethonium in vivo -- D. Effect of Decamethonium, Suxamethonium and Acetylcholine on the Electrical Properties of Single Mammalian Muscle Cells -- E. Depolarisation Versus Desensitisation -- F. Species Differences and Depolarising Neuromuscular Blocking Drugs -- G. Factors which May Modify the Action of Depolarising Neuromuscular Blocking Drugs and Variations Due to Experimental Conditions -- H. Concluding Remarks --
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| 505 |
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|a Appendix III An Outline of the Methods Used to Calculate the Quantal Content of the e.p.p. and the Rate of Refilling and Size of the ACh Store in Nerve Terminals -- References -- 5A The Clinician Looks at Neuromuscular Blocking Drugs -- A. Introduction -- B. General Anaesthesia before Neuromuscular Blocking Drugs -- C. Clinical Influence of Neuromuscular Blocking Drugs -- D. Three Possibly Fatal Reactions to Suxamethonium -- E. Less Serious Reactions to Suxamethonium -- F. Personal Technique -- G. Conclusions -- References -- 5B Neuromuscular Blocking Drugs in Man -- A. Introduction -- B. Measurement of Drug Action -- C. Pharmacokinetics of Neuromuscular Blocking Drugs -- D. Action of Neuromuscular Blocking Drugs at the Neuromuscular Junction -- E. Other Actions of Neuromuscular Blocking Drugs -- References -- 5C Twenty Years’ Experience with Decamethonium -- A. Introduction -- B. First Clinical Reports -- C. Analysis of 32000 Administrations of Decamethonium -- D. Assessment --
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| 505 |
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|a References -- Author Index
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| 505 |
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|a References -- 4B Competitive Neuromuscular Blocking Drugs -- A. Introduction and Terminology -- B. Chemical Structure -- C. Methods Used to Measure Neuromuscular Blockade -- D. Distribution of Competitive Neuromuscular Blocking Drugs -- E. Factors Affecting Duration of Action in Animals and Man -- F. Mechanism of Action at Neuromuscular Junction -- G. Effects at Cholinergic Synapses in the Autonomic Nervous System -- H. Histamine Release in Animals and Man -- J. Miscellaneous Drugs which Cause Muscle Paralysis -- References -- 4C Pharmacology of Anticholinesterase Drugs -- A. Introduction -- B. Morphology and Function of Acetylcholinesterase (AChE) -- C. Inhibition of AChE -- D. Actions of Anticholinesterases of the Carbamate and Organophosphate Type and of Anilinium Ions -- General Conclusions -- Appendix I Studies on Frog Muscles -- Appendix II Anticholinesterases and Anilinium Ions Referred to in the Text --
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| 505 |
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|a Introductory Chapter The Neuromuscular Junction: Areas of Uncertainty -- Neuromuscular Block by Prolonged Depolarisation -- Desensitisation -- The Clinical Picture -- The Presence of Other Drugs -- The Importance of the Drug Structure and that of the Acetylcholine Receptor -- Pre-Synaptic or Post-Synaptic Action? -- Closing Remarks -- References -- 1 The Anatomy and Pathology of the Neuromuscular Junction -- A. Introduction -- B. Normal Muscle -- C. Development, Growth, and Plasticity of the Neuromuscular Junction -- D. The Neuromuscular Junction in Disorders of Transmission -- E. The Neuromuscular Junction in Disorders of the Muscle Fibre -- F. Conclusion -- References -- 2 Neurochemistry of Cholinergic Terminals -- A. Introduction -- B. Methods for Extracting and Measuring Acetylcholine -- C. Acetylcholine Synthesis -- D. Acetylcholine Storage -- E. Acetylcholine Release -- F. Acetylcholine Turnover -- G. Removal of Acetylcholine --
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| 653 |
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|a Medical sciences
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| 653 |
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|a Pharmacy
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| 653 |
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|a Health Sciences
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| 700 |
1 |
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|a Collier, B.
|e [author]
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| 700 |
1 |
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|a Dripps, R.D.
|e [author]
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| 700 |
1 |
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|a Duchen, L.W.
|e [author]
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| 041 |
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7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b SBA
|a Springer Book Archives -2004
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| 490 |
0 |
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|a Handbook of Experimental Pharmacology
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| 028 |
5 |
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|a 10.1007/978-3-642-45476-9
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| 856 |
4 |
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|u https://doi.org/10.1007/978-3-642-45476-9?nosfx=y
|x Verlag
|3 Volltext
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| 082 |
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|a 610
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| 520 |
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|a Has the neuromuscular junction been over-exposed or is it perhaps already a closed book? I asked myself this at a recent International Congress when an American colleague complained that the Journal of Physiology had articles on nothing but the neuromuscular junction, while another colleague asked why I was editing a volume on a subject about which everything was already known. It is worrying to think that these views may be shared by other people. I hope that this volume will convince my two colleagues and other readers that the neuromuscular junction is very much alive and continues to attract the interest of many workers from a variety of fields; strange as it may seem, the synapse between a motor nerve ending and muscle fibre, with its relatively simple architecture, is one of the most inter esting sites in the body-I do hope we have done it justice. The various chapters of this volume present a cross section of knowledge as viewed by a group of 13 individuals, actively engaged in research. Multi-author volumes such as this are frequently criticised on the grounds that chapters or sec tions overlap. I believe that such criticium is only valid where the overlap is repetitious. Where it results in the reader having available discussions of material from differing stand-points, overlap becomes a valuable feature of this type of publication
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