The Biochemistry of Glycoproteins and Proteoglycans
Although glycoproteins and proteoglycans have been a subject of re search for many years, it is only during the last five or so years that they have aroused the interest of a very broad cross section of investigators in the biological sciences. The reason for this expanded interest in these molecul...
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| Format: | eBook |
| Language: | English |
| Published: |
New York, NY
Springer US
1980, 1980
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| Edition: | 1st ed. 1980 |
| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- 3 Mammalian Glycosyltransferases: Their Role in the Synthesis and Function of Complex Carbohydrates and Glycolipids
- A 1. Introduction
- 2. Glycosyltransferases Involved in Elongation of N-Glycosidically Linked Oligosaccharides of the N-Acetyllactosamine type
- 3. Glycosyltransferases Involved in Synthesis of O-Glycosidically Linked Oligosaccharides
- B 1. Introduction
- 2. New Gangliosides
- 3. Occurrence and Subcellular Distribution
- 4. Gangliosides as Membrane Components
- 5. Biosynthesis and Degradation
- 6. Effect of Cell Transformation on Ganglioside Synthesis
- 7. Gangliosides in Development and Differentiation
- 8. Gangliosides as Membrane Receptors for Toxins and Hormones
- 9. References
- 4 Surface Carbohydrate Alterations of Mutant Mammalian Cells Selected for Resistance to Plant Lectins
- 1. Selection of Cells with Altered Surface Carbohydrate
- 2. Biochemical Basis of a Surface Carbohydrate Alteration
- 2. Galactose-Binding Receptor of Mammalian Hepatocytes
- 3. N-Acetylglucosamine-Binding Receptor of Avian Hepatocytes
- 4. Mannose-6-Phosphate Recognition System of Human Fibroblasts
- 5. Mannose/N-Acetylglucosamine Recognition System of Reticuloendothelial Cells
- 6. Fucose Recognition System of Mammalian Hepatocytes
- 7. Concluding Remarks
- 8. References
- 7 Structure and Metabolism of Connective Tissue Proteoglycans
- 1. Introduction
- 2. Hyaluronic Acid
- 3. Chondroitin Sulfate Proteoglycans
- 4. Keratan Sulfate
- 5. Heparin and Heparan Sulfate Proteoglycans
- 6. Dermatan Sulfate
- 7. References
- 1 Structure of Glycoproteins and their Oligosaccharide Units
- 1. Introduction
- 2. Isolation and Structural Analysis of Glycopeptides
- 3. Glycopeptides Containing Oligosaccharides Linked O-Glycosidically to the Peptide
- 4. Glycopeptides Containing the N-Acetylglucosaminyl-Asparagine Linkage
- 5. Role of Oligosaccharides in Glycoprotein Synthesis
- 6. References
- 2 The Function of Saccharide-Lipids in Synthesis of Glycoproteins
- 1. Introduction
- 2. Dolichol
- 3. Monoglycosyl Derivatives of Dolichol Phosphate
- 4. Assembly of Oligosaccharide-Lipids
- 5. Transfer of Oligosaccharide Chains to Endogenous Membrane Proteins
- 6. Transfer of the Oligosaccharide Chains from Oligosaccharide-Lipids to Exogenous, Soluble Proteins
- 7. A Model for Glycosylation of Membrane and Secretory Glycoproteins
- 8. Regulation of Glycoprotein Synthesis
- 9. Inhibitors of Glycosylation
- 10. References
- 3. Genetic and Biochemical Properties of Glt1? CHO Cells
- 4. Surface Carbohydrate Alterations of Other Lectin-Resistant (LecR) Cell Lines
- 5. Membrane Properties of LecR Cells Possessing Specific Carbohydrate Alterations
- 6. Properties of Other LecR Cell Lines
- 7. Mechanisms of Lectin Cytotoxicity
- 8. Glycosylation Mutants Selected Without the Use of Lectins
- 9. Concluding Remarks
- 10. References
- 5 Alterations in Glycoproteins of the Cell Surface
- 1. Introduction
- 2. Growth-Dependent Changes in Asparagine-Linked Oligosaccharides of Membrane Glycoproteins
- 3. Transformation-Dependent Changes in Asparagine-Linked Glycopeptides
- 4. Changes in Serine- (Threonine-) Linked Oligosaccharides of Membrane Glycoproteins
- 5. Alterations in Glycosaminoglycans
- 6. Use of Endoglycosidases for Detecting Alterations in Cell Surface Glycopeptides
- 7. References
- 6 Carbohydrate Recognition Systems for Receptor-Mediated Pinocytosis
- 1. Introduction