Advances in Human Genetics 10
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| Format: | eBook |
| Language: | English |
| Published: |
New York, NY
Springer US
1980, 1980
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| Edition: | 1st ed. 1980 |
| Series: | Advances in Human Genetics
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| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- 1 Biochemistry and Genetics of the ABO, Lewis, and P Blood Group Systems
- The ABO System
- The Lewis System
- The P System
- Serology and Genetics
- Chemistry of P1, P, and Pk Determinants
- Biosynthetic Pathways
- Relationship between ABH and P Systems
- Concluding Remarks
- References
- 2 HLA—A Central Immunological Agency of Man
- HLA: A Supergene
- HLA Terminology
- Inheritance of HLA
- The HLA-A, -B, and -C Allelic Series of Antigens
- HLA-D
- Cell-Mediated Lympholysis (CML)
- HLA-DR
- Population Genetics
- The HLA “Supergene” and Transplantation
- Evolution and Maintenance of the MHC—Function?
- What of the Future?
- References
- 3 Linkage Analysis in Man
- General Considerations
- Historical Perspective
- Approach to Family Studies
- Preparation of Data Prior to Analysis
- Analysis of Data
- Interpretation of Results
- Multipoint Mapping
- Significance of Linkage
- References
- 4 Sister Chromatid Exchanges
- BrdUrd Methodology for SCE Detection
- Basic Information about SCEs
- Induction of Sister Chromatid Exchange by Clastogens
- Extension of SCE Studies from in Vitro to in Vivo Systems
- Interpretation of SCE Induction Tests
- Relationship of SCE Induction to DNA Damage, Repair, and Synthesis
- Relationship of SCE Induction to Mutagenesis
- Sister Chromatid Differentiation in Meiotic Cells
- Sister Chromatid Exchange Formation in Heritable Human Diseases
- Studies of the Mechanism of SCE Formation
- References
- 5 Genetic Disorders of Male Sexual Differentiation
- Normal Male Sex Differentiation in the Fetus
- Abnormal Male Sex Differentiation
- References
- Addenda