Issues and Reviews in Teratology Volume 2

A growing sophistication of the American populace about the nature and realities of the impact of the environment on prenatal development was not much in evi­ dence in 1983. Continuing accusations against Agent Orange and Bendectin high­ light what must be a deep credulousness and need to blame othe...

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Bibliographic Details
Other Authors: Kalter, Harold (Editor)
Format: eBook
Language:English
Published: New York, NY Springer US 1984, 1984
Edition:1st ed. 1984
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • 13. Fetal Sensitivity in Animals Relative to Humans: Conclusions
  • 14. Summary
  • References
  • 5 Transplacental Exposure to Diethylstilbestrol
  • 1. Introduction
  • 2. Clinical Research
  • 3. Animal Research
  • 4. Mechanism of Transplacental Carcinogenesis
  • References
  • 6 Hormones, Growth Factors, and Their Receptors in Normal and Abnormal Prenatal Development
  • 1. Introduction
  • 2. Steroids
  • 3. Growth Hormones and Factors
  • 4. Dioxins and Their Receptors in Teratology
  • 5. Benzodiazepine and Opiate Receptors
  • 6. Summary and Conclusions
  • References
  • 7 Vertebrate Limb Morphogenesis: A Review of Normal Development in a Model Experimental System with Applications toward Understanding Abnormal Limb Formation
  • 1. Introduction
  • 2. The Apical Ectodermal Ridge
  • 3. Mesoderm and Limb Patterns
  • 4. Extracellular Matrix
  • 5. Cell Death
  • 6. Limb Mutants
  • 7. Dysmorphogenesis
  • 8. Summary
  • References
  • 8 Teratogenicity of Experimental and Occupational Exposure to Industrial Chemicals
  • 1. Introduction
  • 2. Alcohols (Ethanol)
  • 3. Aldehydes
  • 1 Birth Defects Monitoring Systems: Accomplishments and Goals
  • 1. Introduction
  • 2. Further Reasons for Registering Malformations
  • 3. Fundamentals of Malformation Registration
  • 4. What Should Be Monitored?
  • 5. The Problem of Ascertainment
  • 6. Size of Population Monitored
  • 7. Properties of Monitoring Systems and Ascertainment Rates
  • 8. Detection of Changes in Prevalence
  • 9. Limitations and Benefits of Monitoring Systems
  • References
  • 2 What Is a Teratogen? Epidemiological Criteria
  • 1. Introduction
  • 2. Definition of a Teratogen
  • 3. Criteria of Judgment in Epidemiology
  • 4. Dealing with Doubt
  • 5. Raising the Alert
  • 6. Conclusion
  • References
  • 3 Congenital Hydrocephalus in Mice and Man
  • 1. Introduction
  • 2. Teratology
  • 3. Discussion
  • References
  • 4 Congenital Defects of Domestic and Feral Animals
  • 1. Introduction
  • 2. Definitions
  • 3. Nature and Effect
  • 4. Frequency
  • 5. Causes
  • 6. Specific Defects
  • 7. Conclusions
  • References
  • 4. Heavy Metals
  • 5. Halogenated Hydrocarbons (Chlorinated Solvents)
  • 6. Ketones
  • 7. Organic Solvents
  • 8. Plastics and Related Chemicals
  • 9. Chlorobenzenes and Carbon Monoxide
  • 10. Discussion and Conclusions
  • References
  • 9 Critical Assessment of Genetic Effects of Ionizing Radiation on Pre- and Postnatal Development
  • 1. Introduction
  • 2. Prologue
  • 3. The Human Experience
  • 4. Permissible Exposures
  • 5. Future Directions
  • 6. Glossary
  • References
  • 10 Adverse Effects in Humans and Animals of Prenatal Exposure to Selected Therapeutic Drugs and Estimation of Embryo-Fetal Sensitivity of Animals for Human Risk Assessment: A Review
  • 1. Introduction
  • 2. Aspirin and Salicylates
  • 3. Progestational Agents
  • 4. Anticonvulsant Drugs
  • 5. Phenothiazines
  • 6. Meprobamate
  • 7. Pregnancy Toxemia and Reserpine
  • 8. Thalidomide
  • 9. Isoniazid
  • 10. Tetracyclines
  • 11. Aminopterin
  • 12. Methotrexate