Nutritional Elements and Clinical Biochemistry

The important role that the nutritional status exerts in determining the course of life from birth to death in the human being and especially its impact in disease states is only par­ tially appreciated at this time. Nutritional deficiencies are usually considered to be major problems only in under-...

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Bibliographic Details
Main Author: Brewster, Marge A.
Other Authors: Naito, Herbert K. (Editor)
Format: eBook
Language:English
Published: Boston, MA Springer US 1980, 1980
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
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245 0 0 |a Nutritional Elements and Clinical Biochemistry  |h Elektronische Ressource  |c edited by Marge A. Brewster, Herbert K. Naito 
260 |a Boston, MA  |b Springer US  |c 1980, 1980 
300 |a XIV, 464 p. 5 illus  |b online resource 
505 0 |a Clinical and Pathophysiological Considerations -- 1. Historical Aspects -- 2. Characteristics of Megaloblastic Anemias -- 3. Vitamin B12 Deficiency -- 4. Folic Acid Deficiency -- 5. Inborn Errors of Metabolism Resulting in Megaloblastic Anemia and Megaloblastic Anemia in Children -- 6. References --  
505 0 |a Effects of Hypoproteinemia on Serum Lipoprotein Composition of Dogs and Rats -- 1. Introduction -- 2. Methods -- 3. Results -- 4. Discussion -- 5. References -- Dietary Fiber and Disease -- 1. Atherosclerosis -- 2. Colon Carcinogenesis -- 3. Diabetes Mellitus -- 4. References -- Some Manifestations of Malabsorption in Disease -- 1. Review of Assimilation of Nutrients -- 2. Abnormalities Associated with Malabsorption -- 3. Activity of Intestinal Microflora -- 4. References -- Amino Acids in Health and Disease -- 1. Protein Requirements -- 2. Factors Affecting Plasma Amino Acid Concentrations -- 3. References -- Aminograms in Various Types of Liver Disease -- 1. Introduction -- 2. Materials -- 3. Methods -- 4. Results -- 5. Discussion -- 6. References -- The Role of Erythrocyte Amino Acids in Energy Metabolism -- 1. Introduction -- 2. Utilization of Amino Acids by the Liver and Kidney for Gluconeogenesis -- 3. Transport of Amino Acids for Gluconeogenesis -- 4. References -- Contributo 
505 0 |a Clinical Correlates in Nutritional Disease -- 1. Fetal Growth -- 2. Postnatal Growth -- 3. References -- Clinical Significance of Riboflavin Deficiency -- 1. Structure and Chemical-Physical Properties -- 2. Metabolism and Functions -- 3. Requirements -- 4. Assessment of Riboflavin Status -- 5. Occurrence of Riboflavin Deficiency -- 6. Causes of Deficiency -- 7. Effects of Riboflavin Deficiency -- 8. References -- Role of Vitamin C in Health and Disease -- 1. Synthesis -- 2. Catabolism -- 3. Physiology -- 4. Recommended Daily Allowances -- 5. Toxic Effects of Large Vitamin C Intake -- 6. Vitamin C Deficiency -- 7. Methods of Assessing Vitamin C Adequacy -- 8. References -- Vitamin A and Retinol Binding Protein Alterations in Disease -- 1. Vitamin A Chemistry, Metabolism and function -- 2. Retinol Binding Proteins -- 3. Vitamin A and Retinol Binding Proteins in Cancer -- 4. References -- Vitamin D - Its Excessive Use in the U.S.A. --  
505 0 |a the Prudent Polyunsaturated Fat Diet -- 1. Rationale of the Diet Parameters -- 2. Development of the Therapeutic Diet -- 3. Practical Considerations -- 4. Modifications of the Prudent Polyunsaturated Fat Diet -- 5. Patient Adherence -- 6. Summary and Sample Menus -- 7. References --  
653 |a Science (General) 
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520 |a The important role that the nutritional status exerts in determining the course of life from birth to death in the human being and especially its impact in disease states is only par­ tially appreciated at this time. Nutritional deficiencies are usually considered to be major problems only in under-privileged or developing populations, except for those occurring in specific diseases. This attitude is incorrect as indicated by reports of Bestrian et al (1974, 1976) and Merritt and Suskin (1979) and others who found evidence of nutritional depletion in as much as 50% of the patients in varied groups of hospitalized patients in the United States. Other studies, some of which are included in this book, emphasized the existence of deficiencies of certain specific nutrients. Despite evidence of nutritional deficiencies occurring more frequently than previously appreciated, there is no well established protocol of laboratory studies that the clinical chemist or scientist should provide to help the physician detect lack of essential nutrients before extensive and possibly irreparable damage has occurred to the individual patient. Considerable research data are needed to determine the best biologic material (i.e., erythrocytes, leucocytes, plasma, serum, urine, cerebrospinal fluid, lymph) for analysis to determine accurately at an early stage metabolic deficiencies due to a specific nutritional element. Improved techniques for analysis of key metabolites and nutrients are available in the research labora­ tory and many of them can be adapted to the clinical laboratory