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Chemical Mutagens Principles and Methods for Their Detection

Volume 9 of Chemical Mutagens consists mainly of chapters discussing the development and validation of short-term assays to detect the mutagenic effects of environmental chemicals. These chapters include an assay with the grasshopper neuroblast, a comparison of mutagenic responses of human lung-deri...

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Bibliographic Details
Other Authors: Hollaender, Alexander (Editor), de Serres, Frederick J. (Editor)
Format: eBook
Language:English
Published: New York, NY Springer US 1984, 1984
Edition:1st ed. 1984
Subjects:
Environmental Chemistry
Medical Genetics
Waste Management/waste Technology
Pharmacology
Oncology
Refuse And Refuse Disposal
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • 3. Hypersensitivity of Repair Mutants to DNA-Damaging Agents
  • 4. Rapid Detection of DNA-Damaging Agents by Differential Cytotoxicity (DC)
  • 5. Conclusions
  • 6. References
  • 8 Transplacental Genotoxic Agents: Cytogenetic Methods for Their Detection
  • 1. Introduction
  • 2. Animal Studies
  • 3. Human Studies
  • 4. References
  • 9 Computer Automation of Metaphase Finding, Sister Chromatid Exchange, and Chromosome Damage Analysis
  • 1. Introduction
  • 2. Historical Trends in Computer Automation
  • 3. Development of a System for Cytogenetic Mutagenicity Testing
  • 4. Future Prospects for Full Automation
  • 5. References
  • 10 Mutagen-Sensitive Mutants and Chemical Mutagenesis in Drosaphila
  • 1. Introduction
  • 2. Isolation and Localization of Mutants
  • 3. Biochemical Characteristics
  • 4. Larval Exposure
  • 5. Adult Exposure
  • 6. Maternal Effects
  • 7. Storage Effect
  • 8. Conclusions
  • 9. References
  • 11 Chromosomal Causes for Fertility Reduction in Mammals
  • 1. Introduction
  • 2. Numerical Chromosome Mutations of the Sex Chromosomes and Related Conditions
  • 3. Structural Chromosome Anomalies
  • 4. Combinations of Chromosome Mutants within One Carrier
  • 5. Viable Unbalanced Progeny Obtained from Translocation Heterozygote Females and Males
  • 6. Why is Chromosomal Infertility More Clearly Expressed in the Male Than in the Female? Consideration of X-Autosome Translocations
  • 7. References
  • 12 Mutagenesis and Plasmids
  • 1. Introduction
  • 2. Historical Overview of Plasmids
  • 3. Survey of Thirty-Three R Plasmids
  • 4. Mechanisms of Plasmid-Mediated Effects on Mutagenesis and Survival
  • 5. References
  • 13 Mutation in Somatic Cells as Determined by Electrophoretic Analysis of Mutagen-Exposed Chinese Hamster Ovary Cells
  • 1. Introduction.-3. Results and Discussion
  • 4. Summary
  • 5. References
  • 5. Detection and Study of Other Translocations and of Inversions
  • 6. Detection and Study of Deletions
  • 7. Conclusions
  • 8. References
  • 4 Cytogenetic Assays for Mitotic Poisons Using Somatic Animal Cells
  • 1. Introduction
  • 2. Mitotic Poisons and Their Genomic Effects
  • 3. Assays with Diploid Mammalian Cells in Vitro
  • 4. Assays with Bone Marrow Cells in Vivo
  • 5. Assays with Grasshopper Embryos
  • 6. Conclusions
  • 7. References
  • 5 Detection of Aneuploidy in Drosophila
  • 1. Introduction
  • 2. Issues
  • 3. Assay Systems
  • 4. Known Positives
  • 5. Summary
  • 6. References
  • 6 Mammalian Cytogenetic and Genetic Tests for Nondisjunction
  • 1. Introduction
  • 2. Cytogenetic Tests
  • 3. Genetic Test Systems with the Mouse
  • 4. Summary and Conclusions
  • 5. References
  • 7 Using Repair-Deficient Chinese Hamster Ovary Cells to Study Mutagenesis
  • 1. Introduction
  • 2. Genetic and Biochemical Properties of Repair-Deficient Mutants
  • 1 In Vivo Mutagenicity Testing Using Somatic Cells of Drosophila melanogaster
  • 1. Introduction
  • 2. Basic Developmental Biology of Drosophila
  • 3. The Wing Mosaic System
  • 4. The White/White-Coral Eye Mosaic System
  • 5. The Unstable White-Zeste Eye Mosaic System
  • 6. Exposure Techniques
  • 7. Discussion
  • 8. Conclusions
  • 9. References
  • 2 Structural and Metabolic Parameters Governing the Mutagenicity of Polycyclic Aromatic Hydrocarbons
  • 1. Introduction
  • 2. Activation Pathways of PAHs
  • 3. Contribution of Different Activation Pathways to the Mutagenicity of PAHs
  • 4. Metabolic Control of Mutagenic Intermediates of PAHs
  • 5. Summary and Conclusions
  • 6. Addendum: Recent Developments
  • 7. References
  • 3 Chromosomal Mutations: The Genetic Approach
  • 1. Introduction
  • 2. The Main Categories of Chromosomal Mutation
  • 3. Genetic Detection of Aneuploidy in the Mouse
  • 4. Reciprocal Translocations: Detection and Analysis

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