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Leukolysins and Cancer

Regulation of malignant cell growth by the immune system has been extensively studied by cancer researchers hoping to develop immuno­ therapeutic approaches to cancer management. For years these studies revolved around the recognition and destruction of tumors by cytotox. ic immune effector cells. R...

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Bibliographic Details
Other Authors: Ransom, Janet H. (Editor), Ortaldo, John R. (Editor)
Format: eBook
Language:English
Published: Totowa, NJ Humana 1988, 1988
Edition:1st ed. 1988
Series:Contemporary Biomedicine
Subjects:
Oncology
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • Clinical Aspects of Interferon Therapy in Human Cancer
  • Antiproliferative and Clinical Antitumor Effects of Interferons
  • Biologic Effects of Tumor Necrosis Factors Alpha and Beta
  • Leukoregulin: Potential as a Clinical Cancer Therapeutic Agent
  • 3. Preparation of Leukoregulin
  • 4. Pathways of Leukoregulin Action
  • 5. Role of Leukoregulin in Homeostasis and Pathophysiology
  • 6. Therapeutic Implications and Research Directions
  • References
  • Lymphotoxins: Mediators of Cellular Activation, Inflammation, and Cell Lysis That Are Immunologically Related to Macrophage Toxins and Tumor Necrosis Factors
  • 1. Introduction
  • 2. Studies of Lymphotoxin from Normal Lymphocytes
  • 3. Immunological Relationships of LT-1, LT-2, LT-3, MCT, and TNF
  • 4. Effects of Lymphotoxins on Cells In Vitro
  • 5. Antitumor Effects of Lymphotoxins In Vivo
  • 6. Lymphotoxins as Inducers of Inflammation
  • 7. Conclusion
  • References
  • Tumor Necrosis Factors Alpha and Beta: A Family of Biochemically Related Cytokines
  • 1. History of Tumor Necrosis Factors
  • 2. Nomenclature: In Vivo Necrosis Activities
  • 3. HuTNF-? and HuTNF-?: Biochemistry and Molecular Biology
  • 4. Summary
  • References
  • 2. Clinical Applications Interferons
  • 1. Biology and Biochemistry
  • Cytolytic Pore-Forming Proteins
  • Cytolysin: Its Purification, Biological Properties, and Mechanisms of Action
  • Monocyte Cytotoxic Factors
  • Triggering of a Cytolytic Factor with TNF-Like Activity From Human Monocytes
  • 1. Introduction
  • 2. Results and Discussion
  • 2.3. Target-Cell Selectivity and Capacity to Induce CM Production in Monocytes
  • References
  • Antitumor Monocyte Cytotoxic Factors (MCF) Produced by Human Blood Monocytes: Production, Characterization, and Biological Significance
  • 1. Introduction
  • 2. Generation of MCF
  • 3. Lytic Activity of MCF
  • 4. Biochemical and Biophysical Characteristics of MCF
  • 5. Biological Significance of MCF
  • 6. Conclusion
  • References
  • Antiproliferative Effects of Interferon
  • 1. Introduction
  • 2. Structure of Interferon
  • 3. Interferon Receptors
  • 4. Mechanisms of Action
  • 5. In Vitro Antiproliferative Effects
  • 6. Structure-Function Relationships
  • 7. In Vivo Tumor Biology
  • 8. Conclusion
  • References
  • Natural Killer Cell Cytotoxic Factor
  • Human and Rodent Natural Killer Cytotoxic Factors (NKCF): Characterization and Their Role in the NK Lytic Mechanism
  • 1. Introduction
  • 2. Materials and Methods
  • 3. Results and Discussion
  • 4. Concluding Remarks
  • References
  • Human Natural Killer Cytotoxic Factor (NKCF): Relevance, Mode of Action, and Relationship to Other Cytotoxic Factors
  • 1. Introduction
  • 2. Results
  • 3. Discussion
  • References
  • Natural Killer Cell Cytotoxic Factor
  • 1. Introduction
  • 2. Biology of NKCF
  • 3. Biochemistry of NKCF
  • 4. Mechanism of Action of NKCF
  • 5. Future Studies
  • References
  • Leukoregulin
  • Leukoregulin: Biology, Biochemistry, and Mode of Action
  • 1. Introduction
  • 2. Biology of Leukoregulin
  • 3. Physicochemical Characteristics of Leukoregulin
  • 4. Conclusions
  • References
  • Leukoregulin Mechanisms of Anticancer Action
  • 1. Discovery of Leukoregulin
  • 2. Assays Defining Leukoregulin Activity

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