The alpha-1 Adrenergic Receptors

During the past decade, great strides have been made in our un­ derstanding of the biochemistry and pharmacology of the alpha-l adrenergic receptor. The alpha-l adrenergic receptor plays a key role in biological function. This is evidenced by the fact that the alpha-l adrenergic receptor plays a pro...

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Bibliographic Details
Main Author: Ruffolo, Jr
Format: eBook
Language:English
Published: Totowa, NJ Humana 1987, 1987
Edition:1st ed. 1987
Series:The Receptors
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • Section 1: Historical Perspectives
  • 1 alpha-1 Adrenergic Receptors: A Historical Perspective
  • Section 2: Characterization of the Receptor and Its Binding Site
  • 2 Biochemistry and Pharmacology of the alpha-1 Adrenergic Receptor
  • 3 Localizing the alpha-1 Adrenergic Receptor in the Central Nervous System: Relating Pharmacology to Structure and Function
  • Section 3: Biochemical Mechanism of Receptor Action
  • 4 Ca2+ Utilization in Signal Transformation of alpha-1 Adrenergic Receptors
  • 5 Phosphoinositides and alpha-1 Adrenergic Receptors
  • Section 4: Correlation of Receptor Binding and Function
  • 6 Structure-Activity Relationships for alpha-1 Adrenergic Receptor Agonists and Antagonists
  • 7 Relationship of alpha-1 Adrenergic Receptor Occupancy to Tissue Response
  • 8 Heterogeneity of alpha-1 Adrenergic Receptors
  • 9 Heterogeneity of alpha-Adrenergic Responsiveness in Vascular Smooth Muscle: Role of Receptor Subtypes and Receptor Reserve
  • 10 alpha-1 Adrenergic Receptors in the Central Nervous System
  • Section 5: Regulation of alpha-1 Adrenergic Receptors
  • 11 Regulation of alpha-1 Adrenergic Receptors
  • Section 6: Agents Interacting with alpha-1 Adrenergic Receptors
  • 12 Therapeutic Applications of Agents Interacting with alpha-1 Adrenergic Receptors
  • Section 7: Future Vistas
  • 13 alpha-1 Adrenergic Receptors: Summary and Future Vistas