The Tachykinin Receptors

Offers a state-of-the-art review by international experts on all aspects of tachykinin receptors, including neuropeptide/peptide and G-protein-linked receptors in general. It covers the physiology, pharmacology, biochemistry, and molecular biology of these receptors from both clinical and basic rese...

Full description

Bibliographic Details
Main Author: Buck, Stephen H.
Format: eBook
Language:English
Published: Totowa, NJ Humana 1994, 1994
Edition:1st ed. 1994
Series:The Receptors
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • I. Historical Perspectives of Tachykinins
  • 1 History of Tachykinin Peptides 1
  • 2 History of Tachykinin Receptors 23
  • II. Characterization of Tachykinin Receptors
  • 3 Biochemical Methods and Assays 39
  • 4 Agonist and Antagonist Receptor Binding
  • 5 Comparative Distribution of Receptor Types in the Mammalian Brain 101
  • 6 Autoradiographic Localization of Receptors in Peripheral Tissues 125
  • 7 Molecular Biology of Receptors: Structures, Expression,and Regulatory Mechanisms 165
  • 8 Characterization of the NKl Receptor Using Photoaffinity Probes 219
  • 9 Modeling of G-Protein-Coupled Receptors: Application to the NK1Tachykinin Receptor 237
  • III. Mechanisms of Tachykinin Receptor Action
  • 10 Receptors and the Inositol Phosphate—Calcium Signaling System 257
  • 11 Signal Transduction Mechanisms of Tachykinin Effects on Ion Channels 285
  • IV. Tachykinin Receptor Function
  • 12 Structure—Activity Relationships of Agonist and Antagonist Ligands 329
  • 13 Pharmacological Characterization of Receptor Types 367
  • 14 Evidence for Receptor Subtypes/Species Variants of Receptors. 395
  • 15 Role of Receptors in Nociception 471
  • 16 Pharmacological Characterization of Receptors in the Spinal Cord of the Newborn Rat 499
  • 17•Receptor Function in the Periphery 515
  • 18 Receptor Involvement in Pathology and Disease 581
  • V. Summary and Future Perspectives
  • 19 Summary, Thoughts, and Future Perspectives 611