The Tachykinin Receptors
Offers a state-of-the-art review by international experts on all aspects of tachykinin receptors, including neuropeptide/peptide and G-protein-linked receptors in general. It covers the physiology, pharmacology, biochemistry, and molecular biology of these receptors from both clinical and basic rese...
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Format: | eBook |
Language: | English |
Published: |
Totowa, NJ
Humana
1994, 1994
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Edition: | 1st ed. 1994 |
Series: | The Receptors
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Subjects: | |
Online Access: | |
Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- I. Historical Perspectives of Tachykinins
- 1 History of Tachykinin Peptides 1
- 2 History of Tachykinin Receptors 23
- II. Characterization of Tachykinin Receptors
- 3 Biochemical Methods and Assays 39
- 4 Agonist and Antagonist Receptor Binding
- 5 Comparative Distribution of Receptor Types in the Mammalian Brain 101
- 6 Autoradiographic Localization of Receptors in Peripheral Tissues 125
- 7 Molecular Biology of Receptors: Structures, Expression,and Regulatory Mechanisms 165
- 8 Characterization of the NKl Receptor Using Photoaffinity Probes 219
- 9 Modeling of G-Protein-Coupled Receptors: Application to the NK1Tachykinin Receptor 237
- III. Mechanisms of Tachykinin Receptor Action
- 10 Receptors and the Inositol Phosphate—Calcium Signaling System 257
- 11 Signal Transduction Mechanisms of Tachykinin Effects on Ion Channels 285
- IV. Tachykinin Receptor Function
- 12 Structure—Activity Relationships of Agonist and Antagonist Ligands 329
- 13 Pharmacological Characterization of Receptor Types 367
- 14 Evidence for Receptor Subtypes/Species Variants of Receptors. 395
- 15 Role of Receptors in Nociception 471
- 16 Pharmacological Characterization of Receptors in the Spinal Cord of the Newborn Rat 499
- 17•Receptor Function in the Periphery 515
- 18 Receptor Involvement in Pathology and Disease 581
- V. Summary and Future Perspectives
- 19 Summary, Thoughts, and Future Perspectives 611