The Intervertebral Disc Molecular and Structural Studies of the Disc in Health and Disease

The intervertebral disc is composed of a complex tissue that separates neighboring vertebrae, permits a wide range of motion, and cushions the high biomechanical forces on the spine. Disc degeneration leads to a loss of function and is often associated with excruciating pain. Written by leading scie...

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Bibliographic Details
Other Authors: Shapiro, Irving M. (Editor), Risbud, Makarand V. (Editor)
Format: eBook
Language:English
Published: Vienna Springer Vienna 2014, 2014
Edition:1st ed. 2014
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Biomechanical and Molecular Studies of the Intervertebral Disc: Introduction to the Structure, Function and Comparative Anatomy of the Vertebrae and the Intervertebral Disc
  • The Intervertebral Disc: Overview of Disc Mechanics
  • Development of the Intervertebral Disc
  • Proteoglycans of the Intervertebral Disc
  • Collagen and Other Proteins of the Nucleus Pulposus, Annulus Fibrosus and Cartilage Endplates
  • Microenvironmental Regulation of Cell Function and Extracellular Matrix Synthesis by Disc Cells
  • The Effects of Mechanical Forces on Nucleus and Annulus Cells
  • The Role of the ADAMTS Proteins in the Intervertebral Disc
  • Intervertebral Disc Disease: Pathogenesis and Current Treatment Modalities: Epidemiology of Lumbar Disc Degeneration
  • Genetic Basis of Intervertebral Disc Degeneration
  • Pathogenesis of Intervertebral Disc Degeneration
  • Imaging Modalities for Studying Disc Pathology
  • Surgical Indications for Lumbar Degenerative Disease
  • Spinal Motion Restoration Devices for the Degenerate Disc
  • The Non-Surgical Treatment of Back Pain
  • Back Pain and Disc Degeneration: Are They Linked?- Clinical Features and Pathobiology of Chordoma
  • Models of Disc Disease and Biological Regeneration: Large Animal Models of Disc Degeneration
  • Intervertebral Disc Herniation
  • The Sand Rat (Psammomys obesus obesus) Model of Spontaneous, Age-Related Intervertebral Disc Generation
  • Use of Knockout and Transgenic Mouse Models in Disc Research
  • Intervertebral Disc Culture Models and Their Applications to Study Pathogenesis and Repair
  • Use of Stem Cells to Regenerate the Disc
  • Gene Therapy Approaches for Disc Regeneration
  • Enhancing Disc Repair by Growth Factors and Other Modalities
  • Tissue Engineering of the Disc