Metabolomics Tools for Natural Product Discovery Methods and Protocols

Classical natural product chemistry is transitioning to modern day metabolomics as a result of the advent of comprehensive analytical platforms and sensitive analytical instrumentation. Therefore, it is worthwhile to summarize recent developments with current analytical platforms and highlight how m...

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Bibliographic Details
Other Authors: Roessner, Ute (Editor), Dias, Daniel Anthony (Editor)
Format: eBook
Language:English
Published: Totowa, NJ Humana 2013, 2013
Edition:1st ed. 2013
Series:Methods in Molecular Biology
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Bryophytes: Liverworts, Mosses and Hornworts – Extraction and Isolation Procedures
  • Plant Tissue Extraction for Metabolomics
  • Detection of Polar Metabolites through the use of Gas Chromatography – Mass Spectrometry
  • A Robust GC-MS Method for the Quantitation of Fatty Acids in Biological Systems
  • A Workflow from Untargeted LC-MS Profiling to Targeted Natural Product Isolation
  • Lipidomics –Extraction Protocols for Biological Matrices
  • Metabolite Analysis of Biological Fluids and Tissues by Proton Nuclear Magnetic Resonance Spectroscopy
  • NMR Spectroscopy: Structure Elucidation of Cycloelatenene A: A Natural Product Case Study
  • NMR-Based Metabolomics: A Probe to Utilize Biodiversity
  • Extraction Protocol for Non-Targeted NMR and LC-MS Metabolomics-Based Analysis of Hard Coral and their Algal Symbionts
  • Determination of Absolute Configuration Using Single Crystal X-ray Diffraction
  • Natural Product Chemistry in Action:  The Synthesis of Melatonin Metabolites K1 and K2
  • Discovery, Biosynthesis, and Rational Engineering of Novel Enterocin and WailupemycinPolyketide Analogues
  • Bioassays for Anticancer Activities
  • Screening for Anti-Diabetic Activities
  • Screening for Antibacterial, Antifungal and Anti-Quorum Sensing Activity
  • Metabolomics and Dereplication Strategies in Natural Products
  • Bridging the Gap: Basic Metabolomics Methods for Natural Product Chemistry
  • Strategies in Biomarker Discovery. Peak Annotation by MS and Targeted LC-MS Micro-Fractionation for de novo Structure Identification by Micro-NMR
  • Statistical Analysis of Metabolomics Data