Occupational Asthma

Population studies, either general population studies, or work force based studies, have contributed enormously to our understanding of disease etiology and in the costs related to the disease. Issues in the design of such studies are discussed to assist the readers in designing and conducting their...

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Corporate Author: SpringerLink (Online service)
Other Authors: Sigsgaard, Torben (Editor), Heederik, Dick (Editor)
Format: eBook
Language:English
Published: Basel Birkhäuser Basel 2010, 2010
Edition:1st ed. 2010
Series:Progress in Inflammation Research
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
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100 1 |a Sigsgaard, Torben  |e [editor] 
245 0 0 |a Occupational Asthma  |h Elektronische Ressource  |c edited by Torben Sigsgaard, Dick Heederik 
250 |a 1st ed. 2010 
260 |a Basel  |b Birkhäuser Basel  |c 2010, 2010 
300 |a XIII, 358 p  |b online resource 
505 0 |a Using apprentices as a powerful cohort design for studying occupational asthma -- Management of an individual worker with occupational asthma -- Social consequences and quality of life in work-related asthma -- Prevention of work-related 
653 |a Occupational Medicine/Industrial Medicine 
653 |a Pneumology 
653 |a Toxicology 
653 |a Immunology 
653 |a Pneumology/Respiratory System 
653 |a Immunology 
653 |a Medicine, Industrial 
653 |a Allergy 
653 |a Allergology 
653 |a Pharmacology/Toxicology 
700 1 |a Heederik, Dick  |e [editor] 
710 2 |a SpringerLink (Online service) 
041 0 7 |a eng  |2 ISO 639-2 
989 |b Springer  |a Springer eBooks 2005- 
490 0 |a Progress in Inflammation Research 
856 |u https://doi.org/10.1007/978-3-7643-8556-9?nosfx=y  |x Verlag  |3 Volltext 
082 0 |a 616.9803 
520 |a Population studies, either general population studies, or work force based studies, have contributed enormously to our understanding of disease etiology and in the costs related to the disease. Issues in the design of such studies are discussed to assist the readers in designing and conducting their own study. Altogether this book gives a comprehensive insight in the present developments which will change the occupational asthma field the coming years 
520 |a Specific attention is given to whole genome screening approaches which involve with present technological possibilities the analysis of thousands of single nucleotide polymorphisms, versus the more focused candidate gene approach where genes with potential mechanistic plausibility are considered. Although the latter approach has been used more extensively, whole genome screening studies are becoming available soon, also for studies on occupational asthma. Management, prevention and surveillance are covered as well. All three areas are undergoing some changes in perception because of the exposure response relationships unraveled during the last decade. Diagnostic rules are introduced to rationalize the diagnostic workup and improve the cost benefit of surveillance schemes, and in preventive measures at large. This approach is only recently introduced in the field of occupational asthma and is expected to contribute even more in the coming years.  
520 |a Recent developments in the field of occupational asthma research and clinical practice are the topic of this volume. The contribution of occupational exposures to chemical and biological agents to the burden of asthma in adults is clearly described in an overview of the most recent epidemiological data from both general population and industry based studies. Emphasis is put on powerful approaches like the use of apprentices studies, which include young individuals, naïve with regard to occupational exposures. Diagnostic criteria for work related and work aggravated asthma are introduced and the latest insights in underlying mechanisms are covered as well. Specific emphasis is given to exposure response relationships for allergen exposure, which opens opportunities for primary and secondary prevention. Large gene-environment studies are undertaken for asthma and their contribution to understanding occupational asthma is discussed.