Store-operated Ca2+ entry (SOCE) pathways Emerging signaling concepts in human (patho)physiology

Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their...

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Corporate Author: SpringerLink (Online service)
Other Authors: Groschner, Klaus (Editor), Graier, Wolfgang F. (Editor), Romanin, Christoph (Editor)
Format: eBook
Published: Vienna Springer Vienna 2012, 2012
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Cardiovascular system. TRPC/Orai-containing channels, Na+/Ca2+ + exchanger and Ca2+ handling in hypertension (V. A. Golovina)
  • 3.4: Cardiovascular system. SOCE and TRPC/STIM/Orai signaling in cardiac myocytes (H. Watanabe, T. Ohba, H. Ito)
  • 3.5: Cardiovascular system. SOCE as a determinant of cardiac pacemaker activity (D.G. Allen, Y. K. Ju, J. Liu, M. S. Imtiaz)
  • 3.6: Cardiovascular system. SOCE and Ca2+ handling in platelet dysfunction (J. J. Lopez, G. M. Salido, J. A. Rosado)
  • 3.7: Cardiovascular system. Store-operated Ca2+ entry in endothelial pathophysiology (K. Groschner, M. Poteser)
  • 3.8: Nervous system. Pathophysiological perspective of neuronal store-operated Ca2+ signaling (S. Bollimuntha, B. Pani, B. B. Singh)
  • 3.9: Skeletal muscle. Store-operated Ca2+ entry and STIM/Orai signaling in skeletal muscle (J. A. Stiber, P. B. Rosenberg)
  • Skeletal muscle. Store-operated channels and Ca2+ handling in muscular dystrophy (U. T. Ruegg, G. Shapovalov, K. Jacobson, J. Reutenauer-Patte, H. Ismail, O. M. Dorchies, P. Avdonin)
  • 3.11: Reproductive system. Store-operated Ca2+ entry in germ cells – role in egg activation (Z. Machaty, C. Wang, K. Lee)
  • SOCE – Fundamental mechanistic concepts
  • Introduction (J. W. Putney)
  • 1.1 The STIM-Orai pathway
  • Structural insights into Ca2+ sensing by stromal interaction molecules (P. B. Stathopulos, M. Ikura)
  • 1.2 The STIM-Orai pathway. Orai, the pore-forming subunit of the CRAC channel (P. G. Hogan)
  • 1.3 The STIM-Orai pathway. The interactions between STIM and Orai (R. Schindl, M. Fahrner, M. Muik, I. Derler, C. Romanin)
  • 1.4 STIM-TRP pathways. The STIM1/Orai/TRPC channels multiple Ca2+ influx complexes (J. H. Hong, M. S. Kim, K. P. Lee, J. P. Yuan, S. Muallem)
  • 1.5 STIM-TRP pathways. Function and regulation of TRPC1: Contribution to Ca2+ entry activated by store depletion (I. S. Ambudkar, K. T. Cheng, H. L. Ong, X. Liu)
  • 1.6 Microdomain organization and the role of second messengers. Microdomain organization of SOCE signaling (C. Moreno, L. Vaca)
  • SOCE – Molecular and cellular (patho)physiology
  • Introduction (J. A. Rosado)
  • 3.1 Immune system. SOCE mediated by STIM and Orai genes in immune function and disease (S. Feske)
  • 3.2: Cardiovascular system. STIM1/Orai1-mediated store-operated Ca2+ entry in cardiovascular disease (R. K. Motiani, M. Trebak)
  • Endogenous messengers and mediators (V. M. Bolotina)
  • SECTION 2: SOCE – Crosstalk between organelle and cellular compartments
  • Introduction: Ca2+ signaling and gene regulation: An introduction (A. B. Parekh)
  • 2.1 New aspects of the contribut ion of ER to SOCE regulation. The role of the ER and ER-plasma membrane junctions in the regulation of SOCE (H. Dingsdale, L. Haynes, G. Lur, A. Tepikin)
  • 2.2 New aspects of the contribution of ER to SOCE regulation. The contribution of SERCA to the regulation of SOCE (J. García-Sancho, M. T. Alonso)
  • 2.3 New aspects of the contribution of ER to SOCE regulation. TRPC proteins as a link between plasma membrane ion transport and intracellular Ca2+ stores (A. Bavencoffe, M. X. Zhu)
  • 2.4 The role of mitochondria in the activation/maintenance of SOCE. Store-operated Ca2+ entry and mitochondria (A. Spät, G. Szanda)