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GPCRs: From Deorphanization to Lead Structure Identification

Based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006, the book highlights the following topics: Structure of GPCRs, Design of GPCR Ligands, GPCR Signalling, Deorphanization and Assay Development. All chapters are written by lead...

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Bibliographic Details
Other Authors: Bourne, H. (Editor), Horuk, Richard (Editor), Kuhnke, J. (Editor), Michel, H. (Editor)
Format: eBook
Language:English
Published: Berlin, Heidelberg Springer Berlin Heidelberg 2007, 2007
Edition:1st ed. 2007
Series:Ernst Schering Foundation Symposium Proceedings
Subjects:
Medical Biochemistry
Computational Chemistry
Pharmacology
Medical Microbiology
Chemistry / Data Processing
Clinical Biochemistry
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • G-Proteins and GPCRs: From the Beginning
  • Modeling GPCRs
  • QSAR Modeling of GPCR Ligands: Methodologies and Examples of Applications
  • Privileged Structures in GPCRs
  • Designing Compound Libraries Targeting GPCRs
  • Orphan Seven Transmembrane Receptor Screening
  • The Role of GPCR Dimerisation/Oligomerisation in Receptor Signalling
  • Deorphanization of G-Protein-Coupled Receptors
  • Virus-Encoded G-Protein-Coupled Receptors: Constitutively Active (Dys)Regulators of Cell Function and Their Potential as Drug Target
  • Modulation of GPCR Conformationsby Ligands, G-Proteins, and Arrestins
  • High Content Screening to Monitor G Protein-Coupled Receptor Internalisation
  • High-Throughput Lead Finding and Optimisation for GPCR Targets

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