Free-Radical-Induced DNA Damage and Its Repair A Chemical Perspective

Understanding of the molecular basis of DNA damage and its repair has increased dramatically in recent years, and substantial knowledge now exists concerning the products arising from free-radical attack on DNA. Free-radical DNA damage may lead to mutations, cancer, and cell death. Free radicals hav...

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Bibliographic Details
Main Author: Sonntag, Clemens
Format: eBook
Language:English
Published: Berlin, Heidelberg Springer Berlin Heidelberg 2006, 2006
Edition:1st ed. 2006
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Formation of Reactive Free Radicals in an Aqueous Environment
  • The Hydroxyl Radical
  • Hydrogen Atom and Hydrated Electron
  • Inorganic Radicals
  • Carbon-Centered Radicals
  • Heteroatom-Centered Radicals
  • Peroxyl Radicals
  • Polymer Radicals
  • Nucleobases, Nucleosides and Nucleotides
  • Polynucleotides and Single-Stranded DNA Fragments
  • DNA and Double-Stranded Oligonucleotides
  • Methods