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Animal Models in Diabetes Research

In recent years, human studies have made enormous contributions towards an understanding of the genetic basis of diabetes mellitus; however, most of the experimentation needed for the invention and testing of novel therapeutic approaches cannot be performed in humans.  Thus, there is no alternative...

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Bibliographic Details
Other Authors: Joost, Hans-Georg (Editor), Al-Hasani, Hadi (Editor), Schürmann, Annette (Editor)
Format: eBook
Language:English
Published: Totowa, NJ Humana 2012, 2012
Edition:1st ed. 2012
Series:Methods in Molecular Biology
Subjects:
Medicine / Research
Biology / Research
Endocrinology
Biomedical Research
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • The Non-Obese Diabetic (NOD) Mouse as a Model of Human Type 1 Diabetes
  • Assessment of Diabetic Nephropathy in the Akita Mouse
  • The BB Rat as a Model of Human Type 1 Diabetes
  • Diabetes in Mice with Monogenic Obesity: The db/db Mouse and Its Use in the Study of Cardiac Consequences
  • Pathophysiology and Genetics of Obesity and Diabetes in the New Zealand Obese Mouse: A Model of the Human Metabolic Syndrome
  • The TALLYHO Mouse as a Model of Human Type 2 Diabetes
  • Diet-Induced Diabetes in the Sand Rat (Psammomys obesus)
  • Diabetes in Zucker Diabetic Fatty Rat
  • The GK Rat: A Prototype for the Study of Non-Overweight Type 2 Diabetes?
  • Experimentally Induced Rodent Models of Type 2 Diabetes
  • Investigation and Treatment of Type 2 Diabetes in Nonhuman Primates
  • Determination of Beta-Cell Function: Insulin Secretion of Isolated Islets
  • Determination of Beta-Cell Function: Ion Channel Function in Beta Cells
  • Measurement of Glucose Homeostasis  In Vivo: Glucose and Insulin Tolerance Tests
  • Measurement of Glucose Homeostasis  In Vivo: Combination of Tracers and Clamp Techniques
  • Measurement of Insulin Sensitivity in Skeletal Muscle In Vitro
  • Beta-Cell Autoimmunity
  • Positional Cloning of Diabetes Genes
  • Retinal Digest Preparation: A Method to Study Diabetic Retinopathy
  • Lineage Tracing of Pancreatic Stem Cells and Beta Cell Regeneration
  • Genetic Lineage Tracing of Beta Cell Neogenesis

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