Immunotoxicity Testing : Methods and Protocols

Recent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in human risk assessment. In Immunotoxicity Testing: Methods and Protocols, expert researchers explore these changes, providing the reader with current, lab...

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Corporate Author: SpringerLink (Online service)
Other Authors: Dietert, Rodney R. (Editor)
Format: eBook
Language:English
Published: Totowa, NJ Humana Press 2010, 2010
Edition:1st ed. 2010
Series:Methods in Molecular Biology
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
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245 0 0 |a Immunotoxicity Testing  |h Elektronische Ressource  |b Methods and Protocols  |c edited by Rodney R. Dietert 
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505 0 |a Past and Future -- Overview and Health-Risk Considerations -- Developmental Immunotoxicity (DIT): The Why, When, and How of DIT Testing -- An In Vivo Tiered Approach to Test Immunosensitization by Low Molecular Weight Compounds -- Risk of Autoimmune Disease: Challenges for Immunotoxicity Testing -- Markers of Inflammation -- Evaluating Macrophages in Immunotoxicity Testing -- Immunotoxicity and Host Resistance Models -- Host Resistance Assays Including Bacterial Challenge Models -- Viral Host Resistance Studies -- Parasite Challenge as Host Resistance Models for Immunotoxicity Testing -- Tumor Challenges in Immunotoxicity Testing -- Testing Protocols in Rodents and Other Laboratory Animals -- The T-Dependent Antibody Response to Keyhole Limpet Hemocyanin in Rodents -- The Sheep Erythrocyte T-Dependent Antibody Response (TDAR) -- The Delayed Type Hypersensitivity Assay Using Protein and Xenogeneic Cell Antigens -- The Cytotoxic T Lymphocyte Assay for Evaluat 
653 |a Medical laboratories 
653 |a Toxicology 
653 |a Laboratory Medicine 
653 |a Science, Humanities and Social Sciences, multidisciplinary 
653 |a Pharmacology/Toxicology 
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520 |a Recent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in human risk assessment. In Immunotoxicity Testing: Methods and Protocols, expert researchers explore these changes, providing the reader with current, lab-ready procedures, along with the corresponding background information that is necessary to identify effective testing approaches for chemicals and drugs. Among the first volumes to meld consideration of immunotoxicity testing strategies with a comprehensive presentation of detailed laboratory protocols, chapters include a description of the evolution of immunotoxicity testing, a look at the importance of immunotoxicity testing for health risk reduction, and ideas concerning the future of the field. Composed in the highly successful Methods in Molecular Biology(tm) series format, most chapters contain a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips from the experts on troubleshooting and avoiding known pitfalls. Comprehensive and innovative, Immunotoxicity Testing: Methods and Protocols is a critical, one-stop reference resource for the most important and commonly used laboratory protocols in immunotoxicology