Ligand-Macromolecular Interactions in Drug Discovery Methods and Protocols
Drug research has been greatly transformed by the "omics revolution" and advances in computational tools, combinatorial chemistry, and high throughput screening techniques (HTS). These implements have advanced the ability to identify target molecules that serve as points of attack for futu...
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| Format: | eBook |
| Language: | English |
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Totowa, NJ
Humana
2010, 2010
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| Edition: | 1st ed. 2010 |
| Series: | Methods in Molecular Biology
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| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- Reviews
- An Historical Overview of Drug Discovery
- Ligand Macromolecule Interactions: Theoretical Principles of Molecular Recognition
- X-Ray Crystallography in Drug Discovery
- Virtual Screening of Compound Libraries
- Protocols
- Combinatorial Chemistry and the Synthesis of Compound Libraries
- Ligand-Based Nuclear Magnetic Resonance Screening Techniques
- Isothermal Titration Calorimetry and Differential Scanning Calorimetry
- Adaptive Combinatorial Design of Focused Compound Libraries
- Chemical Microarrays: A New Tool for Discovery Enzyme Inhibitors
- Fluorescence Polarization and Time-Resolved Fluorescence Resonance Energy Transfer Techniques for PI3K Assays
- Small Molecule Protein Interaction Profiling with Functional Protein Microarrays
- Capillary Electrophoresis in Drug Discovery
- SPR in Drug Discovery: Searching Bioactive Compounds in Plant Extracts
- Application of Frontal Affinity Chromatography with Mass Spectrometry (FAC#x2013;MS) for Stereospecific Ligand#x2013;Macromolecule Interaction, Detection and Screening
- GPC Spin Column HPLC#x2013;ESI-MS Methods for Screening Drugs Noncovalently Bound to Proteins
- A Scintillation Proximity Assay for Fatty Acid Amide Hydrolase Compatible with Inhibitor Screening
- A Natural Products Approach to Drug Discovery: Probing Modes of Action of Antitumor Agents by Genome-Scale cDNA Library Screening
- Ligand#x2013;Macromolecule Interactions in Live Cells by Fluorescence Correlation Spectroscopy