Tumor Biomarker Discovery : Methods and Protocols

Through a variety of mechanisms, cancer cells provide the biomarker material that can lead to their own detection, which then grants clinicians the opportunity for non-invasive body fluid and tissue analysis able to indicate the presence of tumors or the level of tumor burden. In Tumor Biomarker Dis...

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Corporate Author: SpringerLink (Online service)
Other Authors: Tainsky, Michael A. (Editor)
Format: eBook
Language:English
Published: Totowa, NJ Humana Press 2009, 2009
Edition:1st ed. 2009
Series:Methods in Molecular Biology
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
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245 0 0 |a Tumor Biomarker Discovery  |h Elektronische Ressource  |b Methods and Protocols  |c edited by Michael A. Tainsky 
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260 |a Totowa, NJ  |b Humana Press  |c 2009, 2009 
300 |a XI, 332 p. 52 illus., 16 illus. in color  |b online resource 
505 0 |a Identification of Tumor-Associated Antigens as Diagnostic and Predictive Biomarkers in Cancer -- Autoantibodies Against Cancer Antigens -- Discovery of Antibody Biomarkers Using Protein Microarrays of Tumor Antigens Cloned in High Throughput -- Analysis of Glycans on Serum Proteins Using Antibody Microarrays -- Glycoproteomic Analysis by Two-Dimensional Electrophoresis -- All-Liquid Separations, Protein Microarrays, and Mass Spectrometry to Interrogate Serum Proteomes: An Application to Serum Glycoproteomics -- Reverse-Phase Protein Microarrays for Theranostics and Patient Tailored Therapy -- Serum Proteomics Using Mass Spectrometry -- Hormones as Biomarkers: Practical Guide to Utilizing Luminex Technologies for Biomarker Research -- High-Throughput Analysis of Serum Antigens Using Sandwich ELISAs on Microarrays -- Tissue Microarrays as a Tool in the Discovery and Validation of Tumor Markers -- Quantitative, Fluorescence-Based In-Situ Assessment of Protein Expression -- Tumor Marker Discovery by Expression Profiling RNA from Formalin Fixed Paraffin Embedded Tissues -- High-Throughput Mutation Screening Using a Single Amplification Condition -- DNA Sequencing of Cancer-Related Genes for Biomarker Discovery -- Analysis of Loss of Heterozygosity in Circulating DNA -- Pharmacogenomics -- Study Designs in Genetic Epidemiology -- Developing Classifiers for the Detection of Cancer Using Multi-Analytes -- Metabolomics of Cancer -- MRI and MRS of Human Brain Tumors -- Magnetic Resonance Spectroscopy of Living Tissues 
653 |a Cancer research 
653 |a Oncology   
653 |a Oncology 
653 |a Cancer Research 
653 |a Laboratory Medicine 
653 |a Laboratory medicine 
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520 |a Through a variety of mechanisms, cancer cells provide the biomarker material that can lead to their own detection, which then grants clinicians the opportunity for non-invasive body fluid and tissue analysis able to indicate the presence of tumors or the level of tumor burden. In Tumor Biomarker Discovery: Methods and Protocols, experts in the field present detailed chapters focused on the use and development of panels of biomarker analytes while covering subjects such as nucleic acids and protein-based technologies, metabolic profiling by analytic means or spectroscopy, as well as study designs for biomarker discovery and validation. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to the topics, lists of the necessary materials or reagents, step-by-step laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Tumor Biomarker Discovery: Methods and Protocols is an ideal guide to the technologies that can be used to discover and validate tumor biomarker panels suitable for the presymptomatic early detection of cancer