Statistical Genetics of Quantitative Traits : Linkage, Maps and QTL

The book introduces the basic concepts and methods that are useful in the statistical analysis and modeling of DNA-based marker and phenotypic data that arise in agriculture, forrestry, experimental biology, and other fields. It concentrates on the linkage analysis of markers, map construction and q...

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Main Authors: Wu, Rongling, Ma, Changxing (Author), Casella, George (Author)
Corporate Author: SpringerLink (Online service)
Format: eBook
Language:English
Published: New York, NY Springer New York 2007, 2007
Edition:1st ed. 2007
Series:Statistics for Biology and Health
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
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505 0 |a Basic Genetics -- Basic Statistics -- Linkage Analysis and Map Construction -- A General Model for Linkage Analysis in Controlled Crosses -- Linkage Analysis with Recombinant Inbred Lines -- Linkage Analysis for Distorted and Misclassified Markers -- Special Considerations in Linkage Analysis -- Marker Analysis of Phenotypes -- The Structure of QTL Mapping -- Interval Mapping with Regression Analysis -- Interval Mapping by Maximum Likelihood Approach -- Threshold and Precision Analysis -- Composite QTL Mapping -- QTL Mapping in Outbred Pedigrees 
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653 |a Genetics / Mathematics 
653 |a Computational Biology/Bioinformatics 
653 |a Bioinformatics 
653 |a Statistics for Life Sciences, Medicine, Health Sciences 
653 |a Animal Genetics and Genomics 
653 |a Plant Genetics and Genomics 
653 |a Biochemistry, general 
653 |a Biochemistry 
653 |a Animal genetics 
653 |a Statistics 
653 |a Plant genetics 
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700 1 |a Casella, George  |e [author] 
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520 |a The book introduces the basic concepts and methods that are useful in the statistical analysis and modeling of DNA-based marker and phenotypic data that arise in agriculture, forrestry, experimental biology, and other fields. It concentrates on the linkage analysis of markers, map construction and quantitative trait locus (QTL) mapping and assumes a background in regression analysis and maximum likelihood approaches. The strengths of this book lie in the construction of general models and algorithms for linkage analysis and QTL mapping in any kind of crossed pedigrees initiated with inbred lines of crops and plant and animal model systems or outbred lines in forest trees and wildlife species. The book includes a detailed description of each approach and the step-by-step demonstration of live-example analyses designed to explain the utilization and usefulness of statistical methods. The book also includes exercise sets and computer codes for all the analyses used. This book can serve as a textbook for graduates and senior undergraduates in genetics, agronomy, forest biology, plant breeding and animal sciences. It will also be useful to researchers and other professionals in the areas of statistics, biology and agriculture. Rongling Wu is Associate Professor of Statistics at the University of Florida, Gainesville. He currently serves as Associate Editor for six genetics and bioinformatics journals. Chang-Xing Ma is Assistant Professor of Biostatistics at the State University of New York at Buffalo. George Casella is Distinguished Professor of Statistics and Distinguished Member of the Genetics Institute at the Univesity of Florida, Gainesville. He is a fellow of the American Statistical Association and the Institute of Mathematical Sciences, and the author of four other statistics books