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The p53 Tumor Suppressor Pathway and Cancer

The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a tran...

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Bibliographic Details
Other Authors: Zambetti, Gerard P. (Editor)
Format: eBook
Language:English
Published: New York, NY Springer US 2005, 2005
Edition:1st ed. 2005
Series:Protein Reviews
Subjects:
Cell Biology
Medical Genetics
Cytology
Medical Biochemistry
Cancer
Biochemistry
Cancer Biology
Clinical Biochemistry
Oncology
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • The p53 Network
  • The Three-Dimensional Structure of p53
  • Transcriptional Activation by p53: Mechanisms and Targeted Genes
  • Transcriptional Repression by the p53 Tumor Suppressor Protein
  • Posttranslational Modifications of p53: Upstream Signaling Pathways
  • p53 in Human Cancer — Somatic and Inherited Mutations and Mutation-independent Mechanisms
  • MDM2 and MDMX Regulators of p53 Activity
  • p53 Family Members: p63 and p73
  • The Oncogenic Activity of p53 Mutants
  • Therapeutic Strategies Based on Pharmacological Modulation of p53 Pathway

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