|
|
|
|
| LEADER |
03780nmm a2200289 u 4500 |
| 001 |
EB000285799 |
| 003 |
EBX01000000000000000050033 |
| 005 |
00000000000000.0 |
| 007 |
cr||||||||||||||||||||| |
| 008 |
090727 ||| eng |
| 020 |
|
|
|a 9781592591350
|
| 050 |
|
4 |
|a RB1-214
|
| 100 |
1 |
|
|a Boultwood, Jacqueline
|e [editor]
|
| 245 |
0 |
0 |
|a Molecular Analysis of Cancer
|h Elektronische Ressource
|c edited by Jacqueline Boultwood, Carrie Fidler
|
| 250 |
|
|
|a 1st ed. 2002
|
| 260 |
|
|
|a Totowa, NJ
|b Humana Press
|c 2002, 2002
|
| 300 |
|
|
|a XII, 304 p
|b online resource
|
| 505 |
0 |
|
|a Molecular Analysis of Cancer -- Detection of Chromosome Abnormalities in Leukemia Using Fluorescence In Situ Hybridization -- Spectral Karyotyping in Cancer Cytogenetics -- Comparative Genomic Hybridization Analysis -- Detection of Chromosomal Deletions by Microsatellite Analysis -- Detection and Quantification of Leukemia-Specific Rearrangements -- Detection of t(2;5)(p23;q35)Translocation by Long-Range PCR of Genomic DNA -- Use of DNA Fingerprinting to Detect Genetic Rearrangements in Human Cancer -- Mutation Analysis of Large Genomic Regions in Tumor DNA Using Single-Strand Conformation Polymorphism -- Mutational Analysis of Oncogenes and Tumor Suppressor Genes in Human Cancer Using Denaturing Gradient Gel Electrophoresis -- Detection of Mutations in Human Cancer Using Nonisotopic RNase Cleavage Assay -- Mutational Analysis of the Neurofibromatosis Type 1 Gene in Childhood Myelodysplastic Syndromes Using a Protein Truncation Assay -- Mutation Analysis of Cancer Using Automated Sequencing -- Detection of Differentially Expressed Genes in Cancer Using Differential Display -- Genomewide Gene Expression Analysis Using cDNA Microarrays -- Gene Expression Profiling in Cancer Using cDNA Microarrays -- Wilms Tumor Gene WT1 as a -- Detection of Aberrant Methylation of the p15 INK4B Gene Promoter -- Clonality Studies in Cancer Based on X Chromosome Inactivation Phenomenon -- 20Telomere Length Changes in Human Cancer -- Measurement of Telomerase Activity in Human Hematopoietic Cells and Neoplastic Disorders
|
| 653 |
|
|
|a Pathology
|
| 700 |
1 |
|
|a Fidler, Carrie
|e [editor]
|
| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
|
| 989 |
|
|
|b SPRPROT
|a Springer Protocols Archive 1981-2004
|
| 490 |
0 |
|
|a Methods in Molecular Medicine
|
| 028 |
5 |
0 |
|a 10.1385/1592591353
|
| 856 |
4 |
0 |
|u https://doi.org/10.1385/1592591353?nosfx=y
|x Verlag
|3 Volltext
|
| 082 |
0 |
|
|a 616.07
|
| 520 |
|
|
|a Molecular biotechnology has in recent years produced significant advances in finding tumor markers useful in diagnosis and in the assessment of disease progression and prognosis. In Molecular Analysis of Cancer, leading researchers in the field describe in step-by-step detail their best state-of-the-art molecular techniques for elucidating the biochemical processes associated with human cancer. Among the techniques presented for identifying chromosomal rearrangements are fluorescent in situ hybridization (FISH), spectral karyotyping (SKY), comparative genomic hybridization (CGH), microsatellite analysis, PCR and RT-PCR, and DNA fingerprinting. Additional methods include SSCP, DGGE, the nonisotopic RNase cleavage assay, and the protein truncation assay and DNA sequencing for identifying mutations. Techniques for the analysis of gene expression include microarray technology and differential display. All these techniques are of great value for identifying genes that are central to cancer development and progression. Comprehensive and state-of-the-art, Molecular Analysis of Cancer not only offers today's researcher a deeper understanding of cancer's molecular pathogenesis, but also provides a detailed examination of each of the major methodologies needed to detect and analyze its associated genetic abnormalities
|